蛋白质热量营养不良时的血清及红细胞叶酸水平以及血清维生素B12水平
Serum and red cell folates, and serum vitamin B 12 in protein calorie malnutrition.
作者信息
Khalil M, Tanios A, Moghazy M, Aref M K, Mahmoud S, el-Lozy M
出版信息
Arch Dis Child. 1973 May;48(5):366-9. doi: 10.1136/adc.48.5.366.
In 22 cases of kwashiorkor, 19 cases of marasmus, and 16 normal controls, red cell folate, serum folate, and serum vitamin B were estimated, and the bone marrow and peripheral blood examined. Erythrocyte folate deficiency was shown in 9 cases of kwashiorkor and 7 cases of marasmus. Serum folate deficiency was present in 14 cases of kwashiorkor and 7 cases of marasmus. Megaloblastosis was found in 45% of cases of kwashiorkor and 37% of cases of marasmus. Megaloblastosis and macrocytosis correlated more with erythrocyte than with serum folate deficiency. Serum vitamin B levels in children with kwashiorkor or marasmus did not differ from those of normal controls. The role of folate deficiency in the pathogenesis of megaloblastosis in protein calorie malnutrition was confirmed.
对22例夸休可尔症患儿、19例消瘦症患儿及16名正常对照者进行了红细胞叶酸、血清叶酸和血清维生素B的测定，并对骨髓和外周血进行了检查。9例夸休可尔症患儿和7例消瘦症患儿出现红细胞叶酸缺乏。14例夸休可尔症患儿和7例消瘦症患儿存在血清叶酸缺乏。45%的夸休可尔症患儿和37%的消瘦症患儿出现巨幼细胞性贫血。巨幼细胞性贫血和大红细胞症与红细胞叶酸缺乏的相关性大于与血清叶酸缺乏的相关性。夸休可尔症或消瘦症患儿的血清维生素B水平与正常对照者无差异。叶酸缺乏在蛋白质 - 热量营养不良所致巨幼细胞性贫血发病机制中的作用得到了证实。
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