McCloskey R V
Infect Immun. 1972 Jul;6(1):21-6. doi: 10.1128/iai.6.1.21-26.1972.
Phagocytosis and killing of Mima polymorpha and Herellea vaginicola by the liver, lungs, spleen, and kidneys from neonatally thymectomized nonwasted mice and their sham-thymectomized litter mates were compared. The removal of M. polymorpha from blood by these organs, measured 2 and 4 hr after intravenous injection of bacteria, was not affected by thymectomy. Because significantly fewer viable organisms persisted in the liver, spleen, and kidneys, it is concluded that bacterial killing increased after thymectomy. Phagocytosis of M. polymorpha by peritoneal macrophages increased in thymectomized mice. Removal of H. vaginicola from the blood by the lungs was greater after thymectomy. Thymectomy did not affect the killing of H. vaginicola by the liver, spleen, lungs, or kidneys. Killing of H. vaginicola by the kidney was less than that by other organs, although this was not affected by thymectomy. Chronic reticuloendothelial stimulation associated with infection was not an adequate explanation for these findings because no wasting syndrome was encountered.
比较了新生期胸腺切除的未消瘦小鼠及其假胸腺切除的同窝仔鼠的肝脏、肺、脾脏和肾脏对多形米玛菌和阴道赫雷菌的吞噬及杀灭作用。静脉注射细菌后2小时和4小时测量这些器官对血液中多形米玛菌的清除情况，胸腺切除对此无影响。由于肝脏、脾脏和肾脏中存活的细菌明显减少，得出结论：胸腺切除后细菌杀灭作用增强。胸腺切除小鼠的腹膜巨噬细胞对多形米玛菌的吞噬作用增强。胸腺切除后肺对血液中阴道赫雷菌的清除作用增强。胸腺切除不影响肝脏、脾脏、肺或肾脏对阴道赫雷菌的杀灭作用。肾脏对阴道赫雷菌的杀灭作用小于其他器官，尽管胸腺切除对此无影响。与感染相关的慢性网状内皮系统刺激不能充分解释这些发现，因为未出现消瘦综合征。
