吡啶鎓化合物的微生物代谢。4-羧基-1-甲基吡啶鎓氯化物代谢脂肪的放射性同位素研究。
Microbial metabolism of pyridinium compounds. Radioisotope studies of the metabolic fat of 4-carboxy-1-methylpyridinium chloride.
作者信息
Wright K A, Cain R B
出版信息
Biochem J. 1972 Jul;128(3):561-8. doi: 10.1042/bj1280561.
Abstract
Extracts of Achromobacter D formed CO(2), methylamine, succinate and formate as metabolic end-products from N-methylisonicotinic acid (4-carboxy-1-methylpyridinium chloride). The origin of the CO(2) in the 4-carboxyl group and of the methylamine in the N-methyl group of N-methylisonicotinate was demonstrated with carboxyl-(14)C- and N-Me-(14)C-labelled substrates respectively. The carbon skeletons of formate and succinate were shown to arise from the C-2 and the C-3-C-6 atoms of the heterocyclic ring respectively by using N-methyl[2,3-(14)C(2)]isonicotinate. This result is consistent with ring cleavage by the organism between C-2 and C-3.
摘要
无色杆菌D的提取物将N-甲基异烟酸（4-羧基-1-甲基吡啶鎓氯化物）代谢生成二氧化碳、甲胺、琥珀酸和甲酸作为代谢终产物。分别用羧基-（14）C和N-甲基-（14）C标记的底物证明了N-甲基异烟酸酯4-羧基中的二氧化碳和N-甲基中的甲胺的来源。通过使用N-甲基[2,3-（14）C₂]异烟酸酯，表明甲酸和琥珀酸的碳骨架分别来自杂环的C-2和C-3-C-6原子。该结果与该生物体在C-2和C-3之间的环裂解一致。
相似文献
1
Microbial metabolism of pyridinium compounds. Radioisotope studies of the metabolic fat of 4-carboxy-1-methylpyridinium chloride.吡啶鎓化合物的微生物代谢。4-羧基-1-甲基吡啶鎓氯化物代谢脂肪的放射性同位素研究。
Biochem J. 1972 Jul;128(3):561-8. doi: 10.1042/bj1280561.
2
Microbial metabolism of pyridinium compounds. Metabolism of 4-carboxy-1-methylpyridinium chloride, a photolytic product of paraquat.吡啶鎓化合物的微生物代谢。百草枯光解产物4-羧基-1-甲基吡啶鎓氯化物的代谢。
Biochem J. 1972 Jul;128(3):543-59. doi: 10.1042/bj1280543.
3
Pyruvate metabolism by a nitrogen-fixing bacterium.一种固氮细菌的丙酮酸代谢
Biochem J. 1965 Aug;96(2):383-9. doi: 10.1042/bj0960383.
4
The bacterial oxidation of N-methylisonicotinate.N-甲基异烟酸的细菌氧化作用。
Biochem J. 1971 May;122(5):58P. doi: 10.1042/bj1220058pa.
5
Microbial degradation of 4-carboxy-1-methyl-pyridinium chloride, a photolytic product of paraquat.百草枯光解产物4-羧基-1-甲基吡啶鎓氯化物的微生物降解
Biochem J. 1970 Jul;118(3):52P-53P. doi: 10.1042/bj1180052p.
6
Oxidation of C-1 compounds by Pseudomonas sp. MS.假单胞菌MS对C-1化合物的氧化作用
Biochem J. 1970 Feb;116(3):357-65. doi: 10.1042/bj1160357.
7
Effects of carbon dioxide on growth and maltose fermentation by Bacteroides amylophilus.二氧化碳对嗜淀粉拟杆菌生长及麦芽糖发酵的影响
J Bacteriol. 1969 May;98(2):668-76. doi: 10.1128/jb.98.2.668-676.1969.
8
The bacterial oxidation of N-methylisonicotinate, a photolytic product of paraquat.百草枯的光解产物N-甲基异烟酸酯的细菌氧化作用
Biochem J. 1972 May;127(5):833-44. doi: 10.1042/bj1270833.
9
Microbial degradation of aliphatic branched compounds: isobutyric, 2,2-dimethylmalonic and 2,2-dimethylsuccinic acids.脂肪族支链化合物的微生物降解：异丁酸、2,2-二甲基丙二酸和2,2-二甲基琥珀酸
Experientia. 1969 Oct 15;25(10):1032. doi: 10.1007/BF01901407.
10
Carbon assimilation by Pseudomonas oxalaticus (OX 1). 2. Formate and carbon dioxide utilization by cell-free extracts of the organism grown on formate.草酸假单胞菌（OX 1）的碳同化作用。2. 以甲酸盐为碳源生长的该生物体无细胞提取物对甲酸盐和二氧化碳的利用。
Biochem J. 1959 Aug;72(4):631-7. doi: 10.1042/bj0720631.
引用本文的文献
1
Microbial metabolism of pyridine, quinoline, acridine, and their derivatives under aerobic and anaerobic conditions.吡啶、喹啉、吖啶及其衍生物在有氧和无氧条件下的微生物代谢。
Microbiol Rev. 1996 Sep;60(3):483-98. doi: 10.1128/mr.60.3.483-498.1996.
2
Microbial metabolism of pyridinium compounds. Metabolism of 4-carboxy-1-methylpyridinium chloride, a photolytic product of paraquat.吡啶鎓化合物的微生物代谢。百草枯光解产物4-羧基-1-甲基吡啶鎓氯化物的代谢。
Biochem J. 1972 Jul;128(3):543-59. doi: 10.1042/bj1280543.
本文引用的文献
1
The bacterial oxidation of nicotinic acid.烟酸的细菌氧化作用。
J Biol Chem. 1957 Oct;228(2):923-45.
2
Activity of aminoacyl-transfer-ribonucleic acid synthetases in tobacco-leaf tissue in relation to senescence and to the action of 6-furfurylaminopurine.烟草叶片组织中氨酰基转移核糖核酸合成酶的活性与衰老及6-糠氨基嘌呤作用的关系
Biochem J. 1966 Oct;101(1):15-8. doi: 10.1042/bj1010015.
3
The stereospecific removal of a C-19 hydrogen atom in oestrogen biosynthesis.雌激素生物合成过程中C-19氢原子的立体特异性去除。
Biochem J. 1969 Aug;114(1):75-81. doi: 10.1042/bj1140075.
4
The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation.烟酸的代谢。II. 2,5 - 二羟基吡啶氧化、产物形成及氧18掺入
J Biol Chem. 1971 Jun 10;246(11):3743-8.
5
The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9.烟酸的代谢。I. 恶臭假单胞菌N-9中2,5-二羟基吡啶加氧酶的纯化及性质
J Biol Chem. 1971 Jun 10;246(11):3737-42.
6
Microbial metabolism of pyridinium compounds. Metabolism of 4-carboxy-1-methylpyridinium chloride, a photolytic product of paraquat.吡啶鎓化合物的微生物代谢。百草枯光解产物4-羧基-1-甲基吡啶鎓氯化物的代谢。
Biochem J. 1972 Jul;128(3):543-59. doi: 10.1042/bj1280543.
7
The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring.
J Biol Chem. 1969 May 25;244(10):2590-600.
Zotero 插件