Mims C A, Blanden R V
Infect Immun. 1972 Nov;6(5):695-8. doi: 10.1128/iai.6.5.695-698.1972.
Spleen cells from immunized mice were shown to have a strong antiviral action after transfusion into infected recipients. Spleen, liver, and lung titers in recipients were reduced within 24 hr, but there was no detectable effect on brain titer. Spleen cells were active if taken 6 days after infection of donors, when no antibody was detectable. Spleen cell activity was diminished, but by no means abolished, by treatment with potent anti-theta antibody. Immune spleen cells transferred to mice infected 3 days earlier induced early signs of sickness but no change in average survival time. Normal mice injected intracerebrally with a mixture of immune spleen cells plus virus showed unusually early illness and death.
免疫小鼠的脾细胞在输注到受感染的受体后，显示出强大的抗病毒作用。受体的脾脏、肝脏和肺部病毒滴度在24小时内降低，但对脑部病毒滴度没有可检测到的影响。如果在供体感染后6天采集脾细胞，此时检测不到抗体，脾细胞仍然具有活性。用强效抗θ抗体处理后，脾细胞活性降低，但并未完全消除。将免疫脾细胞转移到3天前感染的小鼠中，会诱发早期疾病迹象，但平均存活时间没有变化。正常小鼠脑内注射免疫脾细胞加病毒的混合物后，会出现异常早期疾病和死亡。
