Mason B A, Lessin L, Schechter G P
Am J Med. 1979 Aug;67(2):201-5. doi: 10.1016/0002-9343(79)90391-7.
The bone marrow granulocyte reserves of nine black patients with "benign" neutropenia were estimated by measuring the maximum neutrophil increment after the administration of hydrocortisone. Thirty control subjects, including 16 black and 14 white adults, were also studied. The mean neutrophil increment in the black patients with neutropenia was significantly less than that in the control subjects. The mean increment in the black control was also significantly less than that in the white control subjects. Four of the 16 black control subjects had neutrophil counts below 2,000/microliter; if these four are excluded from the analysis, the difference between the black and white control subjects is no longer significant. These data suggest that there is a subpopulation of healthy black adults with neutrophil counts below 2,000/microliter with reduced marrow granulocyte reserves as tested by corticosteroids. Bone marrow aspirates in four of the neutropenic patients showed normal cellularity and myeloid maturation suggesting that the lower increments are due to a difference in granulocyte release rather than to a difference in granulocyte production.
通过测量给予氢化可的松后中性粒细胞的最大增量，对9例患有“良性”中性粒细胞减少症的黑人患者的骨髓粒细胞储备进行了评估。还研究了30名对照受试者，包括16名黑人成年人和14名白人成年人。患有中性粒细胞减少症的黑人患者的平均中性粒细胞增量明显低于对照受试者。黑人对照组的平均增量也明显低于白人对照受试者。16名黑人对照受试者中有4人的中性粒细胞计数低于2000/微升；如果将这4人排除在分析之外，黑人与白人对照受试者之间的差异就不再显著。这些数据表明，有一部分健康的黑人成年人中性粒细胞计数低于2000/微升，经皮质类固醇检测其骨髓粒细胞储备减少。4例中性粒细胞减少症患者的骨髓穿刺显示细胞数量正常且髓系成熟，这表明较低的增量是由于粒细胞释放的差异而非粒细胞生成的差异。
