Goswami Ritesh, Kakkar Naveen, John M Joseph
1Department of Clinical Haematology, Hemato-oncology and Bone Marrow (Stem Cell) Transplantation, Christian Medical College & Hospital, Brown Road, Ludhiana, 141 008 Punjab India.
2Department of Pathology, Christian Medical College & Hospital, Ludhiana, 141 008 Punjab India.
Indian J Hematol Blood Transfus. 2018 Apr;34(2):278-281. doi: 10.1007/s12288-017-0866-0. Epub 2017 Aug 23.
The total leukocyte count (TLC) is an important component of the complete blood count and influences many clinical decisions. The effect of race or ethnicity on TLC is not well known. The African population has been reported to have lower than normal TLC and neutrophil counts. In this study, thirty eight African students referred for medical check up to a tertiary care hospital were included. Complete blood count was done on a three part automated hematology analyzer. Blood smear examination and manual differential count was also done. The control group included 38 age and sex matched healthy individuals. Student test was used to compare the differences between the groups. The mean TLC in African students (4.95 ± 1.09 × 10/l) was significantly lower ( < 0.0001) than that seen in the control group (7.42 ± 1.7 × 10/l). The mean neutrophil percentage was also lower (49 ± 7.5%) in African students compared to the control group (63.6 ± 9.8%) [ < 0.0001] while lymphocyte percentage was higher (45.2 ± 7.5%) in the African students as compared to the control group (31.0 ± 9.3%) [ < 0.0001]. Absolute neutrophil count was also lower (2.45 ± 0.76 × 10/l) in African students compared to the control group (4.76 ± 1.47 × 10/l) while absolute lymphocyte count was comparable (2.21 ± 0.5 × 10/l vs. 2.26 ± 0.72 × 10/l) [ = 0.7212]. This study has shown lower leukocyte and neutrophil counts in apparently healthy African individuals. Knowledge of this variation from normal white cell and neutrophil counts is important in avoiding unnecessary investigations and influencing therapeutic decisions in these individuals.
白细胞总数（TLC）是全血细胞计数的重要组成部分，会影响许多临床决策。种族或民族对TLC的影响尚不明确。据报道，非洲人群的TLC和中性粒细胞计数低于正常水平。本研究纳入了38名到三级护理医院进行体检的非洲学生。使用三分群自动血液分析仪进行全血细胞计数。同时进行了血涂片检查和手工分类计数。对照组包括38名年龄和性别匹配的健康个体。采用学生t检验比较两组之间的差异。非洲学生的平均TLC（4.95±1.09×10⁹/l）显著低于对照组（7.42±1.7×10⁹/l）（P<0.0001）。与对照组（63.6±9.8%）相比，非洲学生的平均中性粒细胞百分比也较低（49±7.5%）[P<0.0001]，而非洲学生的淋巴细胞百分比（45.2±7.5%）高于对照组（31.0±9.3%）[P<0.0001]。与对照组（4.76±1.47×10⁹/l）相比，非洲学生的绝对中性粒细胞计数也较低（2.45±0.76×10⁹/l），而绝对淋巴细胞计数相当（2.21±0.5×10⁹/l对2.26±0.72×10⁹/l）[P=0.7212]。本研究表明，表面健康的非洲个体的白细胞和中性粒细胞计数较低。了解这种与正常白细胞和中性粒细胞计数的差异，对于避免对这些个体进行不必要的检查以及影响治疗决策具有重要意义。
