Mangan C E, Guintoli R L, Sedlacek T V, Rocereto T, Rubin E, Burtnett M, Mikuta J J
Am J Obstet Gynecol. 1979 Aug 15;134(8):860-5. doi: 10.1016/0002-9378(79)90856-1.
The physician population delivering obstetric care in Philadelphia between 1950 and 1970 was contacted to ascertain their use of diethylstilbesterol (DES) during pregnancy. Of the 31.8% of the physicians who responded to the questionnaire, 71.8% used DES during pregnancy and 12.7% desired assistance in review of their records. During the 6 years from the initial survey, 830 young women exposed to DES in utero were periodically screened for cervicovaginal abnormalities and clear cell adenocarcinoma. Of these 830 patients 61.7% were found to have cervicovaginal abnormalities, and 65.9% of the patients showed either adenosis or evidence of the prior existence of vaginal adenosis. Eight patients were treated for clear cell adenocarcinoma. Two cases were detected while asymptomatic. Seven of the patients are living with no evidence of cancer, and two of these have survived over 5 years.
研究人员联系了1950年至1970年间在费城提供产科护理的医生群体，以确定他们在孕期使用己烯雌酚（DES）的情况。在回复问卷的31.8%的医生中，71.8%在孕期使用了DES，12.7%希望有人协助审查他们的记录。在初次调查后的6年里，对830名子宫内接触过DES的年轻女性定期进行宫颈阴道异常和透明细胞腺癌筛查。在这830名患者中，61.7%被发现有宫颈阴道异常，65.9%的患者表现为腺病或有既往阴道腺病的证据。8名患者接受了透明细胞腺癌治疗。2例在无症状时被检测出。7名患者存活且无癌症迹象，其中2名已存活超过5年。
