Jefferies J A, Robboy S J, O'Brien P C, Bergstralh E J, Labarthe D R, Barnes A B, Noller K L, Hatab P A, Kaufman R H, Townsend D E
Am J Obstet Gynecol. 1984 Jan 1;148(1):59-66. doi: 10.1016/s0002-9378(84)80033-2.
Among women exposed in utero to diethylstilbestrol (DES) and enrolled in the Diethylstilbestrol Adenosis (DESAD) Project, structural anomalies of the cervix or vagina were found in 25% of the 1,655 subjects identified by review of prenatal records, 43% of the 800 who themselves requested entry into the project, and 49% of the 1,089 referred by physicians but in only 2% of the 963 control subjects. Among the 367 cases found by record review to have complete information on the DES exposure, multivariate analysis indicated close association of the anomalies with the gestational week of first exposure and the total dose. Also, the prevalence rate of the anomalies was lower among subjects who had been pregnant and higher among those with later age at menarche.
在子宫内暴露于己烯雌酚（DES）并参与己烯雌酚腺病（DESAD）项目的女性中，通过查阅产前记录确定的1655名受试者中有25%存在宫颈或阴道结构异常，自行要求加入该项目的800名受试者中有43%存在此类异常，由医生转诊的1089名受试者中有49%存在异常，而963名对照受试者中只有2%存在异常。在通过记录审查发现的367例有完整DES暴露信息的病例中，多变量分析表明这些异常与首次暴露的孕周和总剂量密切相关。此外，异常的患病率在已怀孕的受试者中较低，在初潮年龄较大的受试者中较高。
