Mitchell J W, Stolwijk J A, Nadel E R
Biophys J. 1972 Nov;12(11):1452-66. doi: 10.1016/S0006-3495(72)86174-5.
We developed a dynamic model to account for blood flow in the working muscle during step changes in work rate. The model contains a proportional controller based on oxygen tension in the muscle and a description of the various oxygen-equivalent energy stores. Because of nonlinearities only particular solutions can be obtained. Such solutions were obtained via the finite difference method for various work levels and regimens. Model predictions are presented in comparisons with new experimental data, and with data reported in the literature. The changes in oxygen-equivalent energy stores and in muscle blood flow occur very rapidly after onset of exercise, with at least 90% of the steady-state response being reached within 90 sec.
我们开发了一个动态模型,用于解释工作率发生阶跃变化时工作肌肉中的血流情况。该模型包含一个基于肌肉中氧张力的比例控制器以及对各种氧当量能量储备的描述。由于存在非线性,只能获得特定的解。通过有限差分法针对各种工作水平和方案获得了此类解。将模型预测结果与新的实验数据以及文献中报道的数据进行了比较。运动开始后,氧当量能量储备和肌肉血流的变化非常迅速,在90秒内至少达到稳态反应的90%。