Wells D G, Langman M J, Wilson J
Br Med J. 1972 Dec 9;4(5840):588-90. doi: 10.1136/bmj.4.5840.588.
Patients with subacute combined degeneration who smoked had significantly lowered plasma thiocyanate levels than control smokers, but plasma thiocyanate levels in non-smoking patients with neurological disease due to vitamin B(12) deficiency were not significantly different from control values. The results provide no support for the hypothesis that chronic cyanide intoxication is responsible for the occurrence of neurological disease in a minority of patients with vitamin B(12) deficiency, although they do not conclusively exclude this possibility. The association between smoking and subacute combined degeneration of the cord has been confirmed in this study but it remains unexplained.
患有亚急性联合变性的吸烟患者血浆硫氰酸盐水平显著低于对照吸烟者，但因维生素B12缺乏导致神经疾病的非吸烟患者血浆硫氰酸盐水平与对照值无显著差异。这些结果不支持慢性氰化物中毒导致少数维生素B12缺乏患者发生神经疾病这一假说，尽管它们并未确凿排除这种可能性。本研究证实了吸烟与脊髓亚急性联合变性之间的关联，但原因仍不明。
