Maestrone G, Brandt W
Am J Vet Res. 1979 Feb;40(2):285-7.
The therapeutic efficacy of a 0.5% cuprimyxin plus 1% hydrocortisone acetate-water-base suspension was evaluated in 130 clinical cases of otitis externa in dogs and cats in various geographic areas of the United States. The otic microbial flora was studied before treatment in 125 (96%) of the dogs and cats, with multiple isolates recovered from mated from 70%, yeasts from 65%, and fungi from 5% of the animals. Evens though multiple drug reistance was frequently observed in the bacterial flora, all bacteria and yeast isolates were sensitive to cuprimyxin. Of the 130 treated animals, a statistically significant (P less than 0.01) favorable response was obtained in 84,6% and no response in 13;1%; in2.3%, the condition became worse. An adverse reaction (pain at the time of first application) was observed in 1 (0.8%) animal.
在美国不同地理区域的130例犬猫外耳炎临床病例中，评估了0.5%的克菌定加1%的醋酸氢化可的松水基混悬液的治疗效果。在125只（96%）犬猫治疗前研究了耳部微生物菌群，70%的动物分离出多种细菌，65%分离出酵母菌，5%分离出真菌。尽管在细菌菌群中经常观察到多重耐药性，但所有细菌和酵母菌分离株对克菌定均敏感。在130只接受治疗的动物中，84.6%获得了具有统计学意义（P小于0.01）的良好反应，13只（10%）无反应；2.3%的病情恶化。1只（0.8%）动物出现了不良反应（首次用药时疼痛）。
