Plotz P H, Klippel J H, Decker J L, Grauman D, Wolff B, Brown B C, Rutt G
Ann Intern Med. 1979 Aug;91(2):221-3. doi: 10.7326/0003-4819-91-2-221.
The bladder complications of 54 patients treated with oral cyclophosphamide for systemic lupus erythematosus (43) or rheumatoid arthritis (11) were reviewed. During an observation period of 241 patient years, we saw seven cases of acute hemorrhagic cystitis and two cases of transitional cell carcinoma of the bladder. Bladder carcinoma was identified 28 and 60 months after withdrawal of the drug and resulted in the death of one patient. The late-occurring serious toxicities of cyclophosphamide should limit the use of the drug in the treatment of nonmalignant inflammatory rheumatic conditions.
对54例因系统性红斑狼疮（43例）或类风湿性关节炎（11例）接受口服环磷酰胺治疗的患者的膀胱并发症进行了回顾性研究。在241患者年的观察期内，我们发现了7例急性出血性膀胱炎和2例膀胱移行细胞癌。膀胱癌分别在停药后28个月和60个月被发现，其中1例患者死亡。环磷酰胺的迟发性严重毒性应限制其在非恶性炎性风湿性疾病治疗中的应用。
