黑寡妇蜘蛛毒液对龙虾神经肌肉接头的影响。
Effect of black widow spider venom on the lobster neuromuscular junctions.
作者信息
Kawai N, Mauro A, Grundfest H
出版信息
J Gen Physiol. 1972 Dec;60(6):650-64. doi: 10.1085/jgp.60.6.650.
Abstract
The effect of black widow spider venom (BWSV) on the junctions of the lobster nerve-muscle preparation was studied by intracellular recordings. After application of BWSV both excitatory and inhibitory postsynaptic potentials (epsp and ipsp) were augmented then suppressed. The frequency of miniature potentials was markedly increased by BWSV. Summated postsynaptic conductance changes appeared to be responsible for the membrane depolarization and the decrease in effective membrane resistance seen in the early stages of the venom action. In the later stages both excitatory and inhibitory "giant miniature potentials" were evoked. No discernible changes were found in the reversal potential of the epsp and ipsp and in the sensitivity of the postsynaptic membrane. The results indicate that BWSV has a presynaptic action at crustacean neuromuscular junctions.
摘要
通过细胞内记录研究了黑寡妇蜘蛛毒液（BWSV）对龙虾神经 - 肌肉标本连接处的影响。施加BWSV后，兴奋性和抑制性突触后电位（epsp和ipsp）均先增强后受到抑制。BWSV使微小电位的频率显著增加。在毒液作用的早期阶段，总和的突触后电导变化似乎是膜去极化以及有效膜电阻降低的原因。在后期阶段，会诱发兴奋性和抑制性“巨大微小电位”。未发现epsp和ipsp的反转电位以及突触后膜的敏感性有明显变化。结果表明，BWSV在甲壳类动物神经肌肉连接处具有突触前作用。
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