Drusin L M, Topf-Olstein B, Levy-Zombek E
Arch Intern Med. 1979 Aug;139(8):901-4.
In 19 of 20 patients in whom the correct diagnosis of primary or secondary syphilis was not obvious initially, a positive routine admission VDRL test result was the first indication of the correct diagnosis. A retrospective study during a one-month period to correlate hospital admissions by clinical service with required routine admission serologic tests for syphilis disclosed an overall compliance rate of only 37.1% (range, 94.6% to 8.0%). Of the 38 patients who did have a positive admission VDRL test result, 55.3% were falsely positive. The false-positive rate was slightly higher for weakly reactive titers than it was for higher titers. The routine serologic testing program uncovered 129 and 116 new cases of syphilis during 1976 and 1977, respectively. The decision to continue the routine admission VDRL screening program was made because the consequences of an incorrect diagnosis could be very great for an individual patient.
在20例最初原发性或继发性梅毒正确诊断不明显的患者中，有19例患者入院时梅毒血清学试验（VDRL）结果呈阳性是正确诊断的首个线索。一项为期1个月的回顾性研究，旨在将临床科室的入院情况与所需的梅毒入院常规血清学检测结果相关联，结果显示总体符合率仅为37.1%（范围为94.6%至8.0%）。在入院时VDRL检测结果呈阳性的38例患者中，55.3%为假阳性。低滴度弱阳性的假阳性率略高于高滴度。1976年和1977年，常规血清学检测项目分别发现了129例和116例梅毒新病例。之所以决定继续开展入院常规VDRL筛查项目，是因为对个体患者而言，诊断错误的后果可能非常严重。
