Filipponi P, Nicoletti I, Nunzi E, Benedetti Massi M, Bolli G, Santeusanio F
Arch Sci Med (Torino). 1979 Jan-Mar;136(1):17-24.
Following chromatographic separation, the RI method has been used to examine the behaviour of plasmatic androgens in a group of normal subjects, in two patients with Addison's disease and two patients with hypercorticoadrenalism, due respectively to corticoadrenal adenoma and bilateral adenomatous hyperplasia. A significant reduction in adrenal androgens was observed in patients suffering from Addison's disease. The most interesting information, however, was the paradoxical reduction in DHEA and delta 4-A in patients with corticoadrenal hyperfunction.
经过色谱分离后，采用折光指数法对一组正常受试者、两名艾迪生病患者以及两名分别因肾上腺皮质腺瘤和双侧腺瘤样增生导致皮质醇增多症的患者体内血浆雄激素的情况进行了检测。观察到艾迪生病患者的肾上腺雄激素显著减少。然而，最有趣的信息是皮质醇增多症患者的脱氢表雄酮（DHEA）和δ4-雄烯二酮（delta 4-A）反而减少。
