Werneck L C, Novak E M
Arq Neuropsiquiatr. 1979 Mar;37(1):15-27. doi: 10.1590/s0004-282x1979000100003.
A sural nerve and a muscle biopsy study of patients with chronic insecticides poisoning, with teased fiber preparations, routine pathologic studies of nerves and histochemistry of muscle is reported. The sural nerves of ten patients were studied and a teased fiber preparation was done in nine. The tenth patient had only fibrosis and no myelin was found. The sural nerves were abnormal in all patients and the teased fiber preparation resulted in preponderance of type C, D and large amount of G type fibers, according to Dyck's classification. These fibers had enlargement of the axon and myelin sheath, also seen in routine sections. The muscle biopsy with routine and histochemistry methods was done in 8 cases; in 6 there was found signs of denervation; the remaining cases were normal, but these were proximal muscles. The authors conclude that the process primarily interfere with the functions of the axons, with distal axonal degeneration and a dying back phenomen.
本文报道了对慢性杀虫剂中毒患者进行的腓肠神经和肌肉活检研究，包括神经纤维分离标本制备、神经常规病理研究以及肌肉组织化学研究。研究了10例患者的腓肠神经，其中9例进行了神经纤维分离标本制备。第10例患者仅见纤维化，未发现髓鞘。所有患者的腓肠神经均异常，根据戴克分类法，神经纤维分离标本制备显示C型、D型纤维占优势，并有大量G型纤维。这些纤维的轴突和髓鞘均有增粗，在常规切片中也可见到。8例患者进行了肌肉常规和组织化学活检；6例有失神经支配迹象；其余病例正常，但这些是近端肌肉。作者得出结论，该过程主要干扰轴突功能，导致远端轴突变性和回返性死亡现象。
