Le Jambre L F, Martin P J, Webb R F
Aust Vet J. 1979 Apr;55(4):163-6. doi: 10.1111/j.1751-0813.1979.tb15263.x.
Six populations of H. contortus were selected for a study of thiabendazole resistance from a collection of 40 populations made during a survey of the efficiency of thiabendazole on the Northern Tablelands of New South Wales. Based on survey results, 3 of these populations were considered susceptible and the remaining 3 were considered resistant. However, when these populations were compared with a known susceptible strain on the ability of their eggs to hatch in a solution containing thiabendazole and 0.1% NaCl all 6 had significantly greater LC50's. The resistance ratios of the LC50 for each of the 6 populations to that of the known susceptible strain were 5.1, 4.3, 3.2, 3.1, 2.3, and 1.6 respectively. Following dosing of their host with 44 mg/kg thiabendazole the resistance ratios of the survivors increased to 5.4, 5.1, 4.7, 4.4, 3.1 and 2.4. Eggs produced by the F1 generation of the worms surviving 44 mg/kg thiabendazole did not revert back to the lower LC50's of the unselected parents. Rather the LC50 remained at a level near that of a known highly resistant strain of H. contortus.
从新南威尔士州北部台地对噻苯达唑驱虫效果调查时收集的40个捻转血矛线虫群体中，选取了6个群体用于噻苯达唑抗性研究。根据调查结果，其中3个群体被认为是敏感的，其余3个群体被认为具有抗性。然而，当将这些群体与已知敏感株在含有噻苯达唑和0.1%氯化钠的溶液中孵化虫卵的能力进行比较时，所有6个群体的半数致死浓度（LC50）都显著更高。这6个群体的LC50与已知敏感株的LC50的抗性比值分别为5.1、4.3、3.2、3.1、2.3和1.6。在用44毫克/千克噻苯达唑给宿主驱虫后，存活虫体的抗性比值增加到5.4、5.1、4.7、4.4、3.1和2.4。经44毫克/千克噻苯达唑处理后存活的虫体所产的F1代虫卵并未恢复到未筛选亲代较低的LC50水平。相反，LC50仍保持在接近已知高抗性捻转血矛线虫株的水平。
