Purshottam T
Aviat Space Environ Med. 1979 Apr;50(4):343-5.
Plasma concentration of Na+, K+ and Cl- ions did not change significantly whereas that of HCO3- dropped to one-third of its initial value in rats during their 15 min of gasping at a simulated altitude of 10,000 m at 33 degrees C, which was their survival threshold. Administration of methamphetamine (2 mg/kg), imipramine (2 mg/kg) and adrenaline (7 mg/kg) i.p. were ineffective in prolonging the survival time of rats, whereas acetazolamide (40 mg/kg), furosemide (2 mg/kg) and caffeine citrate (10 mg/kg) significantly increased their survival under hypoxia, (p less than 0.001, less than 0.01, and less than 0.05, respectively).
在33摄氏度模拟海拔10000米（这是它们的生存阈值）的环境中，大鼠喘息15分钟期间，血浆中Na⁺、K⁺和Cl⁻离子浓度无显著变化，而HCO₃⁻浓度降至初始值的三分之一。腹腔注射甲基苯丙胺（2毫克/千克）、丙咪嗪（2毫克/千克）和肾上腺素（7毫克/千克）对延长大鼠存活时间无效，而乙酰唑胺（40毫克/千克）、呋塞米（2毫克/千克）和枸橼酸咖啡因（10毫克/千克）显著提高了它们在低氧环境下的存活率（分别为p<0.001、<0.01和<0.05）。
