Phair J P, Watanakunakorn C, Goldberg L, Carleton J
Appl Microbiol. 1972 Dec;24(6):967-71. doi: 10.1128/am.24.6.967-971.1972.
Investigation of the ecology of Staphylococcus aureus on the medical service of the Cincinnati General Hospital was carried out from 1964 to 1970. S. aureus was cultured from 1,442 patients. Overall, there was a progressive increase in the susceptibility of S. aureus to commonly used antibiotics, but not to penicillin. Hospital-acquired S. aureus remained highly resistant to all antibiotics except penicillinase-resistant penicillins. There was a progressive decline in the percentage of hospital-acquired infections from January 1964 to September 1969, followed by a rise during September 1969 to September 1970. No single bacteriophage group predominated among nosocomially acquired S. aureus. Major changes in the hospital environment did not appear to influence the prevalence of nasal carriage or hospital acquisition of S. aureus. This study identified the continuing problem of acquisition of S. aureus in the hospital, but no specific "epidemic strain."
1964年至1970年期间，对辛辛那提总医院医疗服务中的金黄色葡萄球菌生态学进行了调查。从1442名患者中培养出了金黄色葡萄球菌。总体而言，金黄色葡萄球菌对常用抗生素的敏感性呈逐渐上升趋势，但对青霉素不敏感。医院获得性金黄色葡萄球菌除对耐青霉素酶的青霉素外，对所有抗生素仍具有高度耐药性。1964年1月至1969年9月，医院获得性感染的百分比呈逐渐下降趋势，随后在1969年9月至1970年9月期间有所上升。在医院获得性金黄色葡萄球菌中，没有单一的噬菌体组占主导地位。医院环境的重大变化似乎并未影响金黄色葡萄球菌的鼻腔携带率或医院感染率。这项研究确定了医院中持续存在的金黄色葡萄球菌感染问题，但未发现特定的“流行菌株”。
