可使药物、其他外来化合物及内源性底物羟化的重组肝微粒体酶系统。五、细胞色素P - 450和P - 448在3,4 -苯并芘羟化过程中对还原酶的竞争。 - Suppr

Suppr

超能文献

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation.

作者信息

West S B, Lu A Y

出版信息

Arch Biochem Biophys. 1972 Nov;153(1):298-303. doi: 10.1016/0003-9861(72)90448-1.

DOI:10.1016/0003-9861(72)90448-1

PMID:4650614

Abstract

摘要

相似文献

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation.

Arch Biochem Biophys. 1972 Nov;153(1):298-303. doi: 10.1016/0003-9861(72)90448-1.

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IV. Hydroxylation of aniline.

Arch Biochem Biophys. 1972 Nov;153(1):294-7. doi: 10.1016/0003-9861(72)90447-x.

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system.

Mol Pharmacol. 1972 Sep;8(5):490-500.

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. I. Determination of substrate specificity by the cytochrome P-450 and P-448 fractions.

Biochem Biophys Res Commun. 1971 Mar 19;42(6):1200-6. doi: 10.1016/0006-291x(71)90033-7.

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VIII. Different catalytic activities of rabbit and rat cytochromes P-448.

Mol Pharmacol. 1975 Mar;11(2):201-10.

Species differences in the induction of microsomal hemoproteins and 3,4-benzpyrene hydroxylase by phenobarbital and 3-methylcholanthrene.

J Pharmacol Exp Ther. 1970 Oct;175(1):4-11.

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.

J Biol Chem. 1972 Mar 25;247(6):1727-34.

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IX. The formation of a 455-nm metabolite-cytochrome P-450 complex.

Drug Metab Dispos. 1976 Mar-Apr;4(2):190-4.

Liver microsomal electron transport systems. II. The involvement of cytochrome b5 in the NADH-dependent hydroxylation of 3,4-benzpyrene by a reconstituted cytochrome P-448-containing system.

Biochem Biophys Res Commun. 1974 May 20;58(2):516-522. doi: 10.1016/0006-291x(74)90395-7.

Effects of inducers of liver microsomal enzymes on the composition of microsomal hemoprotein.

Adv Cytopharmacol. 1971 May;1:241-7.

引用本文的文献

Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes.

Drug Metab Dispos. 2018 Mar;46(3):197-203. doi: 10.1124/dmd.117.078642. Epub 2017 Dec 12.

The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes.

Drug Metab Rev. 2016 Aug;48(3):453-69. doi: 10.1080/03602532.2016.1221961.

Interactions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncoupling.

Biochemistry. 2013 Jun 11;52(23):4003-13. doi: 10.1021/bi400422a. Epub 2013 May 28.

Formation of P450 · P450 complexes and their effect on P450 function.

Pharmacol Ther. 2012 Mar;133(3):299-310. doi: 10.1016/j.pharmthera.2011.11.009. Epub 2011 Nov 29.

Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2.

Biochemistry. 2005 Feb 22;44(7):2632-41. doi: 10.1021/bi0477900.

The reconstitution of microsomal redox chains. A comparitive analysis of the effectiveness of membrane self-assembly and template binding of electron carriers.

Biochem J. 1974 Oct;144(1):1-9. doi: 10.1042/bj1440001.

Uridine-cytidine kinase. III. Competition between uridine and cytidine for a single enzyme.

Mol Cell Biochem. 1977 Oct 7;17(3):141-6. doi: 10.1007/BF01730833.

Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase in cultured human lymphocytes.

Biochem Genet. 1976 Aug;14(7-8):671-85. doi: 10.1007/BF00485845.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验