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Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. I. Determination of substrate specificity by the cytochrome P-450 and P-448 fractions.

作者信息

Lu A Y, Kuntzman R, West S, Conney A H

出版信息

Biochem Biophys Res Commun. 1971 Mar 19;42(6):1200-6. doi: 10.1016/0006-291x(71)90033-7.

DOI:10.1016/0006-291x(71)90033-7
PMID:5550806
Abstract
摘要

相似文献

1
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. I. Determination of substrate specificity by the cytochrome P-450 and P-448 fractions.可使药物、其他外来化合物和内源性底物羟化的重组肝微粒体酶系统。I. 细胞色素P-450和P-448组分对底物特异性的测定。
Biochem Biophys Res Commun. 1971 Mar 19;42(6):1200-6. doi: 10.1016/0006-291x(71)90033-7.
2
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.可使药物、其他外来化合物及内源性底物羟化的重组肝微粒体酶系统。II. 细胞色素P - 450和P - 448组分在药物和类固醇羟化中的作用。
J Biol Chem. 1972 Mar 25;247(6):1727-34.
3
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation.可使药物、其他外来化合物及内源性底物羟化的重组肝微粒体酶系统。五、细胞色素P - 450和P - 448在3,4 -苯并芘羟化过程中对还原酶的竞争。
Arch Biochem Biophys. 1972 Nov;153(1):298-303. doi: 10.1016/0003-9861(72)90448-1.
4
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VIII. Different catalytic activities of rabbit and rat cytochromes P-448.能够使药物、其他外来化合物和内源性底物发生羟基化反应的重组肝微粒体酶系统。VIII. 兔和大鼠细胞色素P-448的不同催化活性。
Mol Pharmacol. 1975 Mar;11(2):201-10.
5
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IV. Hydroxylation of aniline.可使药物、其他外来化合物及内源性底物羟化的重组肝微粒体酶系统。IV. 苯胺的羟化作用。
Arch Biochem Biophys. 1972 Nov;153(1):294-7. doi: 10.1016/0003-9861(72)90447-x.
6
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system.可使药物、其他外来化合物及内源性底物羟化的重组肝微粒体酶系统。3. 重组3,4-苯并芘羟化酶系统的性质。
Mol Pharmacol. 1972 Sep;8(5):490-500.
7
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats.
J Biol Chem. 1973 Jan 25;248(2):456-60.
8
Species differences in the induction of microsomal hemoproteins and 3,4-benzpyrene hydroxylase by phenobarbital and 3-methylcholanthrene.苯巴比妥和3-甲基胆蒽对微粒体血红蛋白和3,4-苯并芘羟化酶诱导作用的种属差异。
J Pharmacol Exp Ther. 1970 Oct;175(1):4-11.
9
Effects of inducers of liver microsomal enzymes on the composition of microsomal hemoprotein.肝微粒体酶诱导剂对微粒体血红素蛋白组成的影响。
Adv Cytopharmacol. 1971 May;1:241-7.
10
Effect of enzyme induction on the metabolism of benzo(a)pyrene and 3'-methyl-4-monomethylaminoazobenzene in the pregnant and fetal rat.酶诱导对孕鼠和胎鼠体内苯并(a)芘及3'-甲基-4-单甲基氨基偶氮苯代谢的影响。
Cancer Res. 1972 May;32(5):973-8.

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Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.芳烃受体（AHR）：外源性和内源性信号“传感器”的碱性螺旋/环/螺旋Per-Arnt-Sim（bHLH/PAS）家族的“先驱成员”。
Prog Lipid Res. 2017 Jul;67:38-57. doi: 10.1016/j.plipres.2017.06.001. Epub 2017 Jun 9.
2
Is the liver cytochrome P-450-linked biotransformation system lecithin-dependent?肝脏中细胞色素P - 450相关的生物转化系统是否依赖卵磷脂？
Biochem J. 1972 Apr;127(2):37P-38P. doi: 10.1042/bj1270037pb.
3
Metabolism of polycyclic aromatic hydrocarbons in cultured human leukocytes under genetic control.
遗传控制下培养的人白细胞中多环芳烃的代谢
Humangenetik. 1973 Dec 10;20(3):257-63. doi: 10.1007/BF00385737.
4
Genetics of aryl hydrocarbon hydroxylase induction in mice: additive inheritance in crosses between C3H-HeJ and DBA-2J.
Biochem Genet. 1973 Mar;8(3):249-57. doi: 10.1007/BF00486177.
5
Effect of hexachlorobenzene on haem synthesis.六氯苯对血红素合成的影响。
Biochem J. 1972 Sep;129(2):381-7. doi: 10.1042/bj1290381.
6
Inhibitory effect of carbon monoxide on the N- and ring-hydroxylation of 2-acetamidofluorene by hamster hepatic microsomal preparations.一氧化碳对仓鼠肝微粒体制剂中2-乙酰氨基芴的N-羟基化和环羟基化的抑制作用。
Biochem J. 1974 Nov;144(2):427-30. doi: 10.1042/bj1440427.
7
Expression of aryl hydrocarbon hydroxylase induction and suppression of tyrosine aminotransferase induction in somatic-cell hybrids.体细胞杂种中芳烃羟化酶诱导的表达及酪氨酸转氨酶诱导的抑制
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2179-83. doi: 10.1073/pnas.69.8.2179.
8
The reconstitution of microsomal redox chains. A comparitive analysis of the effectiveness of membrane self-assembly and template binding of electron carriers.微粒体氧化还原链的重组。膜自组装与电子载体模板结合有效性的比较分析。
Biochem J. 1974 Oct;144(1):1-9. doi: 10.1042/bj1440001.
9
Role of mixed-function amine oxidases in N-hydroxylation of 2-acetamidofluorene by hamster liver microsomal preparations.混合功能胺氧化酶在仓鼠肝微粒体制剂对2-乙酰氨基芴进行N-羟基化反应中的作用。
Biochem J. 1973 Dec;136(4):1137-40. doi: 10.1042/bj1361137.
10
The metabolism and binding of catecholamines by the hepatic microsomal mixed-function oxidase of the rat.大鼠肝脏微粒体混合功能氧化酶对儿茶酚胺的代谢及结合作用。
Biochem J. 1976 Jul 15;158(1):135-40. doi: 10.1042/bj1580135.