Chuaqui B
Br Heart J. 1979 Apr;41(4):481-5. doi: 10.1136/hrt.41.4.481.
Doerr's theory of the morphogenesis of transposition is discussed with special reference to recent studies by Goor and co-workers and Anderson and associates. The views advanced by all these authors coincide in three points: (a) the description of the reorganisation process occurring at the arterial end of the embryonic heart (a process called by Doerr vectorial bulbus rotation); (b) the pathogenetic interpretation of transposition as the result of an arrest of vectorial bulbus rotation; (c) the recognition of a teratological series or spectrum of anomalies pathogenetically related to transposition. Vectorial bulbus rotation is explained mainly as the result of three largely simultaneous events; bulbar shift, bulbus torsion, and truncus torsion. The spectrum of anomalies related to transposition appears as a close-knit series. Bulbar retraction does not seem to be a necessary condition for the connection of the aorta to the left ventricle.
我们结合古尔及其同事以及安德森及其同事最近的研究，对多尔关于转位形态发生的理论进行了讨论。所有这些作者提出的观点在三个方面是一致的：(a) 对胚胎心脏动脉端发生的重组过程的描述（多尔称之为矢量性球部旋转的过程）；(b) 将转位的发病机制解释为矢量性球部旋转停止的结果；(c) 认识到与转位发病机制相关的一系列畸形或畸形谱。矢量性球部旋转主要被解释为三个基本同时发生的事件的结果；球部移位、球部扭转和干扭转。与转位相关的畸形谱表现为一个紧密相连的系列。球部回缩似乎不是主动脉与左心室连接的必要条件。
