麻醉性拮抗剂的人体药理学
Human pharmacology of narcotic antagonists.
作者信息
Jasinski D R
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):287S-290S. doi: 10.1111/j.1365-2125.1979.tb04702.x.
Abstract
1 Human studies at the Addiction Research Center enable narcotic antagonists to be classified into three subgroups: (1) nalorphine-like agents; (2) pure antagonists; and (3) morphine-like agents. 2 Six narcotic antagonists (pentazocine, nalbuphine, cyclazocine, butorphanol, propiram and buprenorphine) developed in recent years seem to have a lesser abuse potential than codeine or propoxyphene. 3 When adjusted for relative availability of the agents, epidemiological data shows that pentazocine is abused less than codeine or propoxyphene in the US. 4 Recent studies with buprenorphine indicate that this agent would find application both as an analgesic of low abuse potential and as a new type of drug for the treatment of addiction.
摘要
- 成瘾研究中心开展的人体研究使麻醉拮抗剂能够被分为三个亚组：（1）烯丙吗啡样药物；（2）纯拮抗剂；以及（3）吗啡样药物。2. 近年来研发的六种麻醉拮抗剂（喷他佐辛、纳布啡、环唑辛、布托啡诺、丙哌利定和丁丙诺啡）似乎比可待因或丙氧芬的滥用潜力更低。3. 当根据药物的相对可获得性进行调整时，流行病学数据表明在美国喷他佐辛的滥用情况比可待因或丙氧芬更少。4. 最近关于丁丙诺啡的研究表明，这种药物既可以作为一种低滥用潜力的镇痛药，也可以作为一种新型的成瘾治疗药物。
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