Human pharmacology of narcotic antagonists.
作者信息
Jasinski D R
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 3(Suppl 3):287S-290S. doi: 10.1111/j.1365-2125.1979.tb04702.x.
Abstract
1 Human studies at the Addiction Research Center enable narcotic antagonists to be classified into three subgroups: (1) nalorphine-like agents; (2) pure antagonists; and (3) morphine-like agents. 2 Six narcotic antagonists (pentazocine, nalbuphine, cyclazocine, butorphanol, propiram and buprenorphine) developed in recent years seem to have a lesser abuse potential than codeine or propoxyphene. 3 When adjusted for relative availability of the agents, epidemiological data shows that pentazocine is abused less than codeine or propoxyphene in the US. 4 Recent studies with buprenorphine indicate that this agent would find application both as an analgesic of low abuse potential and as a new type of drug for the treatment of addiction.
摘要
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Human pharmacology of narcotic antagonists.
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