前列腺素从兔肾的释放、肾神经刺激对其释放的增加作用以及消炎痛对其的抑制作用。
Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin.
作者信息
Davis H A, Horton E W
出版信息
Br J Pharmacol. 1972 Dec;46(4):658-75. doi: 10.1111/j.1476-5381.1972.tb06891.x.
Abstract
- In each of six experiments, prostaglandins were identified in the renal venous blood of the rabbit. The concentrations in renal venous blood were up to 45 times higher than in aortic blood, suggesting that most of the prostaglandins originate from the kidney.2. Prostaglandins E(2), F(2a) and a prostaglandin of the A, C or B series were estimated by biological assay after solvent partition and column or thin-layer chromatography.3. Prostaglandins E(2) and F(2a) were identified conclusively by combined gas chromatography-mass spectrometry.4. Electrical stimulation of the renal nerve increased the output of prostaglandins.5. Indomethacin (10 mg/kg) injected intravenously, reduced the output of prostaglandins into renal venous blood and prevented the increase in output on renal nerve stimulation.
摘要
在六个实验中的每一个实验里，均在兔肾静脉血中鉴定出了前列腺素。肾静脉血中的浓度比主动脉血中的浓度高出多达45倍，这表明大多数前列腺素源自肾脏。
经溶剂分配以及柱色谱或薄层层析后，通过生物测定法对前列腺素E(2)、F(2a)以及A、C或B系列中的一种前列腺素进行了估算。
通过气相色谱-质谱联用技术最终鉴定出了前列腺素E(2)和F(2a)。
对肾神经进行电刺激会增加前列腺素的输出量。
静脉注射吲哚美辛（10毫克/千克）可减少进入肾静脉血中的前列腺素输出量，并阻止肾神经刺激时输出量的增加。
相似文献
1
Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin.前列腺素从兔肾的释放、肾神经刺激对其释放的增加作用以及消炎痛对其的抑制作用。
Br J Pharmacol. 1972 Dec;46(4):658-75. doi: 10.1111/j.1476-5381.1972.tb06891.x.
2
Identification of prostaglandins in prevertebral venous blood after preganglionic stimulation of the cat superior cervical ganglion.猫颈上神经节节前刺激后椎前静脉血中前列腺素的鉴定。
Br J Pharmacol. 1971 Aug;42(4):569-83. doi: 10.1111/j.1476-5381.1971.tb07141.x.
3
The effect of angiotensin I converting enzyme inhibitor (SQ 20881) on the release of prostaglandins by rabbit kidney, in vivo.血管紧张素I转换酶抑制剂（SQ 20881）对兔肾前列腺素体内释放的影响。
Br J Pharmacol. 1977 Aug;60(4):573-81. doi: 10.1111/j.1476-5381.1977.tb07537.x.
4
Possible influence of intrarenal generation of kinins on prostaglandin release from the rabbit perfused kidney.肾内激肽生成对兔灌注肾前列腺素释放的可能影响。
Br J Pharmacol. 1976 Oct;58(2):165-72. doi: 10.1111/j.1476-5381.1976.tb10392.x.
5
Renal concentrations of prostaglandin E in acute and chronic renal ischemia.
Biochem Biophys Res Commun. 1972 Nov 1;49(3):799-805. doi: 10.1016/0006-291x(72)90481-0.
6
Interactions among renal nerves, prostaglandins, and renal arterial pressure in the regulation of renin release.肾神经、前列腺素与肾动脉压力在肾素释放调节中的相互作用。
Am J Physiol. 1984 Nov;247(5 Pt 2):F706-13. doi: 10.1152/ajprenal.1984.247.5.F706.
7
Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs.前列腺素与阿司匹林类药物产生镇痛作用的机制。
Br J Pharmacol. 1973 Sep;49(1):86-97. doi: 10.1111/j.1476-5381.1973.tb08270.x.
8
Metabolism of prostacyclin in the rabbit kidney.前列环素在兔肾中的代谢
J Biol Chem. 1979 Jan 10;254(1):12-4.
9
Attenuation by bradykinin of adrenergically-induced vasoconstriction in the isolated perfused kidney of the rabbit: relationship to prostaglandin synthesis.缓激肽对兔离体灌注肾脏中肾上腺素能诱导的血管收缩的减弱作用：与前列腺素合成的关系。
Br J Pharmacol. 1979 Oct;67(2):269-75. doi: 10.1111/j.1476-5381.1979.tb08676.x.
10
The effect of indomethacin on the release of prostaglandin E2 and acetylcholine from guinea-pig isolated ileum at rest and during field stimulation.吲哚美辛对豚鼠离体回肠在静息状态及场刺激期间前列腺素E2和乙酰胆碱释放的影响。
Br J Pharmacol. 1974 Jan;50(1):119-24. doi: 10.1111/j.1476-5381.1974.tb09598.x.
引用本文的文献
1
Effects of angiotensin II in fetal sheep and modification of its actions by indomethacin.血管紧张素II对胎羊的作用及吲哚美辛对其作用的影响。
J Physiol. 1995 Aug 15;487(1):147-58. doi: 10.1113/jphysiol.1995.sp020867.
2
Analgesic nephropathy: a reassessment of the role of phenacetin and other analgesics.镇痛剂肾病：对非那西丁及其他镇痛剂作用的重新评估
Drugs. 1982 Jan-Feb;23(1-2):75-149. doi: 10.2165/00003495-198223010-00004.
3
The role of prostaglandins in the alpha- and beta-adrenoceptor mediated renin release response to graded renal nerve stimulation.前列腺素在α和β肾上腺素能受体介导的肾素释放对分级肾神经刺激反应中的作用。
Pflugers Arch. 1981 Jul;391(1):1-8. doi: 10.1007/BF00580685.
4
Stimulation of prostaglandin E2-synthesis by noradrenaline in primary cell cultures from rabbit splenic pulpa is mediated by atypical alpha-adrenoceptors.去甲肾上腺素对兔脾髓原代细胞培养物中前列腺素E2合成的刺激作用是由非典型α-肾上腺素能受体介导的。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Feb;316(1):1-7. doi: 10.1007/BF00507219.
5
Proceedings: The identification of individual prostaglandins using a LKB 9000 gas chromatograph-mass spectrometer.论文集：使用LKB 9000气相色谱 - 质谱仪鉴定单个前列腺素。
Br J Pharmacol. 1974 Sep;52(1):150P.
6
Quantitative and qualitative analyses of isolated lipid droplets from interstitial cells in renal papillae from various species.对来自不同物种肾乳头间质细胞中分离出的脂滴进行定量和定性分析。
Lipids. 1974 Nov;9(11):835-43. doi: 10.1007/BF02532606.
7
Release of prostaglandins from the rabbit perfused kidney: effects of vasoconstrictors.前列腺素从兔灌注肾中的释放：血管收缩剂的作用
Br J Pharmacol. 1974 Apr;50(4):533-8. doi: 10.1111/j.1476-5381.1974.tb08588.x.
8
Profile of circulating vasoactive substances in hemorrhagic shock and their pharmacologic manipulation.失血性休克时循环血管活性物质的概况及其药物调控
J Clin Invest. 1974 Oct;54(4):842-52. doi: 10.1172/JCI107824.
9
Role of renal sympathetic nerves in mediating hypoperfusion of renal cortical microcirculation in experimental congestive heart failure and acute extracellular fluid volume depletion.肾交感神经在实验性充血性心力衰竭和急性细胞外液量减少中介导肾皮质微循环低灌注中的作用。
J Clin Invest. 1985 Nov;76(5):1913-20. doi: 10.1172/JCI112187.
10
Effects of indomethacin on renal hemodynamics and on water and sodium excretion by the isolated dog kidney.
Pflugers Arch. 1975 Jun 26;357(3-4):243-52. doi: 10.1007/BF00585979.
本文引用的文献
1
The identification of prostaglandins E(2), F(2alpha) and A(2) from rabbit kidney medulla.从兔肾髓质中鉴定前列腺素 E(2)、F(2alpha)和 A(2)。
Biochem J. 1967 Dec;105(3):1251-60. doi: 10.1042/bj1051251.
2
RENOMEDULLARY VASODEPRESSOR SUBSTANCE, MEDULLIN: ISOLATION, CHEMICAL CHARACTERIZATION AND PHYSIOLOGICAL PROPERTIES.肾髓质升压物质，髓质素：分离、化学特性及生理特性
Circ Res. 1965 Jul;17:57-77. doi: 10.1161/01.res.17.1.57.
3
Selective passage of prostaglandins across the lung.前列腺素在肺中的选择性转运。
Nature. 1969 Aug 16;223(5207):742-5. doi: 10.1038/223742b0.
4
Neural contrfl of intrarenal blood flow.肾内血流的神经控制。
Am J Physiol. 1968 Nov;215(5):1067-81. doi: 10.1152/ajplegacy.1968.215.5.1067.
5
Vasodilators, intrarenal blood flow, and natriuresis in the dog.犬类中的血管扩张剂、肾内血流与利钠作用
Am J Physiol. 1971 Jul;221(1):92-8. doi: 10.1152/ajplegacy.1971.221.1.92.
6
The escape of the renal blood flow response during sympathetic nerve stimulation.交感神经刺激期间肾血流反应的逃逸。
Angiologica. 1970;7(6):333-43. doi: 10.1159/000157848.
7
A prostaglandin isomerase in cat plasma.猫血浆中的一种前列腺素异构酶。
Biochem J. 1970 Oct;119(5):64P-65P. doi: 10.1042/bj1190064pb.
8
The separation, identification and estimation of prostaglandins in nanogram quantities by combined gas chromatography-mass spectrometry.通过气相色谱-质谱联用技术对纳克量前列腺素进行分离、鉴定和定量分析。
Life Sci I. 1970 Sep 1;9(17):983-8. doi: 10.1016/0024-3205(70)90121-9.
9
Prostaglandins A1,A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds.前列腺素A1、A2和19-羟基A1；它们对平滑肌的作用以及在通过肺和肝门静脉血管床时的失活。
Br J Pharmacol. 1969 Nov;37(3):705-22. doi: 10.1111/j.1476-5381.1969.tb08509.x.
10
Hypertension and the renomedullary prostaglandins: a human study of the antihypertensive effects of PGA 1 .
Ann N Y Acad Sci. 1971 Apr 30;180:218-40. doi: 10.1111/j.1749-6632.1971.tb53194.x.
Zotero 插件