• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.吗啡敏感型神经效应器连接的一个新实例：小鼠输精管中的肾上腺素能传递。
Br J Pharmacol. 1972 Dec;46(4):764-6. doi: 10.1111/j.1476-5381.1972.tb06901.x.
2
Action of morphine on the neuro-effector transmission in the guinea-pig ileum and in the mouse vas deferens.吗啡对豚鼠回肠和小鼠输精管神经效应器传递的作用。
J Physiol. 1980 Oct;307:367-83. doi: 10.1113/jphysiol.1980.sp013440.
3
Inhibition of neuroeffector transmission by morphine in the vas deferens of naive and morphine-treated mice.吗啡对未处理及经吗啡处理小鼠输精管中神经效应器传递的抑制作用。
Br J Pharmacol. 1980;71(1):195-200. doi: 10.1111/j.1476-5381.1980.tb10926.x.
4
The effects of morphine on the release of noradrenaline from the mouse vas deferens.吗啡对小鼠输精管去甲肾上腺素释放的影响。
Br J Pharmacol. 1976 Aug;57(4):551-7. doi: 10.1111/j.1476-5381.1976.tb10384.x.
5
[Analysis of the effect of noradrenaline on the response of the vas deferens of the rat to transmural stimulation].[去甲肾上腺素对大鼠输精管跨壁刺激反应的影响分析]
Fiziol Zh SSSR Im I M Sechenova. 1987 Apr;73(4):483-7.
6
Effects of chronic drug treatment on the sensitivity of mouse vas deferens to drugs.慢性药物治疗对小鼠输精管药物敏感性的影响。
Eur J Pharmacol. 1985 Dec 3;118(3):253-61. doi: 10.1016/0014-2999(85)90136-0.
7
Naloxone elicits an excitatory response in the morphine-tolerant mouse vas deferens.
Neuropharmacology. 1987 Dec;26(12):1815-8. doi: 10.1016/0028-3908(87)90141-9.
8
Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesics.吗啡对小鼠输精管肾上腺素能传递的影响。麻醉性镇痛药激动剂和拮抗剂效能的评估。
Br J Pharmacol. 1975 Mar;53(3):371-81. doi: 10.1111/j.1476-5381.1975.tb07373.x.
9
Calcium reverses the inhibitory action of morphine on neuroeffector transmission in the mouse vas deferens.钙可逆转吗啡对小鼠输精管神经效应器传递的抑制作用。
Brain Res. 1980 Jun 9;191(2):511-22. doi: 10.1016/0006-8993(80)91299-8.
10
Action of morphine on guinea-pig myenteric plexus and mouse vas deferens studied by intracellular recording.通过细胞内记录研究吗啡对豚鼠肠肌间神经丛和小鼠输精管的作用。
Life Sci. 1975 Jul 1;17(1):63-6. doi: 10.1016/0024-3205(75)90236-2.

引用本文的文献

1
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions.五十年来阿片肽研究：现有知识与未解问题。
Mol Pharmacol. 2020 Aug;98(2):96-108. doi: 10.1124/mol.120.119388. Epub 2020 Jun 2.
2
Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor.环阿片肽在μ阿片受体上的等效对映体。
Pept Sci (Hoboken). 2019 Jan;111(1). doi: 10.1002/pep2.24078. Epub 2018 May 25.
3
Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.阿片类/NK1 多靶点配体在未损伤和慢性缩窄性损伤小鼠中的体外特征分析及其镇痛作用。
ACS Chem Neurosci. 2017 Oct 18;8(10):2315-2324. doi: 10.1021/acschemneuro.7b00226. Epub 2017 Jul 26.
4
A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinity μ Opioid Receptor Antagonists.一种环四肽（“环多拉肽”）及其镜像异构体均为高亲和力μ阿片受体拮抗剂。
J Med Chem. 2016 Oct 13;59(19):9243-9254. doi: 10.1021/acs.jmedchem.6b01200. Epub 2016 Oct 3.
5
[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.[Dmt(1)]在第1位用酪氨酸类似物修饰的DALDA类似物。
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3629-31. doi: 10.1016/j.bmcl.2016.06.003. Epub 2016 Jun 3.
6
'Carba'-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode.“卡巴”-卡芬太尼（反式异构体）：一种具有独特结合模式的μ阿片受体（MOR）部分激动剂。
Bioorg Med Chem. 2014 Sep 1;22(17):4581-6. doi: 10.1016/j.bmc.2014.07.033. Epub 2014 Jul 29.
7
[Dmt(1)]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profile.[Dmt(1)]具有增强的μ阿片受体激动剂效力和混合的μ/κ阿片活性特征的DALDA类似物。
Bioorg Med Chem. 2014 Apr 1;22(7):2333-8. doi: 10.1016/j.bmc.2014.02.011. Epub 2014 Feb 19.
8
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.Dmt(1)-DALDA 中净电荷、亲脂性和侧链柔韧性的变化：对阿片样活性和生物分布的影响。
J Med Chem. 2012 Nov 26;55(22):9549-61. doi: 10.1021/jm3008079. Epub 2012 Nov 12.
9
Opioid receptor characterisation of neuronally stimulated isolated human vas deferens.神经元刺激分离的人输精管中阿片受体的特征。
Naunyn Schmiedebergs Arch Pharmacol. 2012 Nov;385(11):1049-52. doi: 10.1007/s00210-012-0769-4. Epub 2012 Jun 15.
10
Bifunctional μ/δ opioid peptides: variation of the type and length of the linker connecting the two components.双功能 μ/δ 阿片肽：连接两个部分的连接体的类型和长度的变化。
Chem Biol Drug Des. 2012 Feb;79(2):186-93. doi: 10.1111/j.1747-0285.2011.01268.x. Epub 2012 Jan 4.

本文引用的文献

1
Effect of morphine on some sympathetically innervated effectors.吗啡对某些受交感神经支配的效应器的作用。
Br J Pharmacol Chemother. 1961 Dec;17(3):539-51. doi: 10.1111/j.1476-5381.1961.tb01141.x.
2
The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.吗啡及相关物质对同轴刺激的豚鼠回肠收缩和乙酰胆碱释放的作用。
Br J Pharmacol Chemother. 1957 Mar;12(1):119-27. doi: 10.1111/j.1476-5381.1957.tb01373.x.
3
The action of morphine on the superior cervical ganglion and on the nictitating membrane of the cat.吗啡对猫颈上神经节及瞬膜的作用。
Br J Pharmacol Chemother. 1957 Mar;12(1):79-85. doi: 10.1111/j.1476-5381.1957.tb01366.x.
4
The effects of hexamethonium, morphine and adrenaline on the output of acetylcholine from the myenteric plexus-longitudinal muscle preparation of the ileum.六甲铵、吗啡和肾上腺素对回肠肌间神经丛-纵行肌标本乙酰胆碱释放量的影响。
Br J Pharmacol. 1970 Nov;40(3):553P-554P.
5
3 H-noradrenaline release and mechanical response in the field stimulated mouse vas deferens.3H-去甲肾上腺素在电场刺激的小鼠输精管中的释放及机械反应
Acta Physiol Scand Suppl. 1971;371:1-18. doi: 10.1111/j.1748-1716.1971.tb05210.x.
6
Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens.家兔门静脉和输精管中肾上腺素能递质释放及失活调控机制的评估
Br J Pharmacol. 1972 Mar;44(3):472-91. doi: 10.1111/j.1476-5381.1972.tb07285.x.

吗啡敏感型神经效应器连接的一个新实例：小鼠输精管中的肾上腺素能传递。

A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.

作者信息

Henderson G, Hughes J, Kosterlitz H W

出版信息

Br J Pharmacol. 1972 Dec;46(4):764-6. doi: 10.1111/j.1476-5381.1972.tb06901.x.

DOI:10.1111/j.1476-5381.1972.tb06901.x
PMID:4655272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666368/
Abstract

The isolated mouse vas deferens possesses an adrenergic excitatory motor innervation which can be inhibited by low concentrations of morphine (ID50=0.5 muM). This effect of morphine is mediated by specific receptors which are blocked by naloxone. Activation of the morphine receptors inhibits noradrenaline release. It is concluded that adrenergic neurotransmission in the mouse vas deferens differs in some important way from that at the more common, morphine-insensitive, adrenergic junctions.

摘要

分离出的小鼠输精管具有肾上腺素能兴奋性运动神经支配，低浓度吗啡（半数抑制浓度=0.5微摩尔）可抑制这种支配。吗啡的这种作用由纳洛酮阻断的特定受体介导。吗啡受体的激活抑制去甲肾上腺素释放。得出的结论是，小鼠输精管中的肾上腺素能神经传递在某些重要方面与更常见的、对吗啡不敏感的肾上腺素能接头处的神经传递不同。