吗啡敏感型神经效应器连接的一个新实例：小鼠输精管中的肾上腺素能传递。
A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.
作者信息
Henderson G, Hughes J, Kosterlitz H W
出版信息
Br J Pharmacol. 1972 Dec;46(4):764-6. doi: 10.1111/j.1476-5381.1972.tb06901.x.
Abstract
The isolated mouse vas deferens possesses an adrenergic excitatory motor innervation which can be inhibited by low concentrations of morphine (ID50=0.5 muM). This effect of morphine is mediated by specific receptors which are blocked by naloxone. Activation of the morphine receptors inhibits noradrenaline release. It is concluded that adrenergic neurotransmission in the mouse vas deferens differs in some important way from that at the more common, morphine-insensitive, adrenergic junctions.
摘要
分离出的小鼠输精管具有肾上腺素能兴奋性运动神经支配，低浓度吗啡（半数抑制浓度=0.5微摩尔）可抑制这种支配。吗啡的这种作用由纳洛酮阻断的特定受体介导。吗啡受体的激活抑制去甲肾上腺素释放。得出的结论是，小鼠输精管中的肾上腺素能神经传递在某些重要方面与更常见的、对吗啡不敏感的肾上腺素能接头处的神经传递不同。
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