Manukian M E
Biull Eksp Biol Med. 1979 Jun;87(6):608-10.
A lesion was induced in the central area of the rabbit cornea as deep as half its thickness, with a trepan 4 mm in diameter. As a stimulant of regeneration, ethanolamine was injected subconjunctivally and subcutaneously. In early stages the control animals showed predominant destructive processes; epithelization was completed on the 15-16th day. A rough leukoma emerged at the deficiency site. Administration of ethanolamine made the proliferative processes in the epithelium and in the ground substance of the cornea start earlier while epithelization was completed on the 10-14th day to form a hardly noteceably leukoma. Ethanolamine has proved to be an adequate stimulant in posttraumatic regeneration of the cornea.
用直径4毫米的环钻在兔角膜中央区域制造一个深度达角膜厚度一半的损伤。作为再生刺激物，将乙醇胺结膜下和皮下注射。早期，对照动物主要表现为破坏过程；上皮化在第15 - 16天完成。缺损部位出现粗糙的白斑。给予乙醇胺使角膜上皮和基质中的增殖过程更早开始，而上皮化在第10 - 14天完成，形成几乎不明显的白斑。已证明乙醇胺是角膜创伤后再生的一种合适刺激物。
