Demaille A, Cappelaere P
Bull Cancer. 1979;66(2):139-45.
Rarity of placental metastasis is only apparent, for only few placentas of cancerous mothers have been examined histologically. However, it may show biological and immunological conditions which are characteristics of foeto-placental unit. During metastatic spread of solid tumors or hematologic malignancies in the mother, tumor emboli may be localized in intervillous spaces, without being real placental metastasis. Rarely tumor emboli are able to invade the struma of chorionic villi and produce true placental metastases: twelve such observations have been published, seven of which were malignant melanomas. It is even more exceptional that metastatic spread reaches the foetus. In most of the cases, it is thus protected against maternal cancer. This historical observation holds true. The fear of transplacental graft to the foetus is not an argument favorable of terminating a cancer associated pregnancy and foetal metastasis of maternal origin are not among the causes of congenital cancers in children.
胎盘转移罕见只是表面现象，因为仅有少数患癌母亲的胎盘接受过组织学检查。然而，它可能展现出胎儿 - 胎盘单位所特有的生物学和免疫学状况。在母亲体内实体瘤或血液系统恶性肿瘤发生转移扩散时，肿瘤栓子可能定位在绒毛间隙，这并非真正的胎盘转移。肿瘤栓子极少能够侵入绒毛膜绒毛基质并产生真正的胎盘转移：已发表了12例此类观察结果，其中7例为恶性黑色素瘤。转移扩散累及胎儿的情况更为罕见。在大多数情况下，胎儿因此受到保护免受母体癌症影响。这一历史观察结果是正确的。担心胎儿经胎盘移植并非支持终止与癌症相关妊娠的理由，而且源自母体的胎儿转移并非儿童先天性癌症的病因之一。
