前列腺素前体及其他不饱和脂肪酸对猫在位心脏传导时间和不应期的作用。
Actions of prostaglandin precursors and other unsaturated fatty acids on conduction time and refractory period in the cat heart in situ.
作者信息
Bayer B L, Förster W
出版信息
Br J Pharmacol. 1979 Jun;66(2):191-5. doi: 10.1111/j.1476-5381.1979.tb13664.x.
Abstract
1 The effect of arachidonic, dihomo-gamma-linolenic, linoleic, alpha-linolenic and oleic acid, given by intravenous infusion, on conduction time and functional refractory period have been studied in the cat heart in situ. 2 The prostaglandin precursors, arachidonic acid and dihomo-gamma-linolenic acid, prolonged the conduction time and the functional refractory period. Linoleic acid was also effective but to a lesser degree. alpha-Linolenic acid and oleic acid showed no or only a weak effect in thie respect. 3 Pretreatment was indomethacin diminished or abolished the actions of the three effective fatty acids but not those of prostaglandin E2. 4 The results suggest that the effects of prostaglandin prostaglandin precursors on conduction time and refractory period are responsible for their antiarrhythmic effectiveness and that these effects are attributable to their endogenous conversion into prostaglandins.
摘要
- 研究了静脉输注花生四烯酸、二高-γ-亚麻酸、亚油酸、α-亚麻酸和油酸对猫原位心脏传导时间和功能不应期的影响。2. 前列腺素前体花生四烯酸和二高-γ-亚麻酸延长了传导时间和功能不应期。亚油酸也有作用，但程度较小。α-亚麻酸和油酸在这方面无作用或仅有微弱作用。3. 吲哚美辛预处理减弱或消除了三种有效脂肪酸的作用，但对前列腺素E2的作用无影响。4. 结果表明，前列腺素前体对传导时间和不应期的影响是其抗心律失常作用的原因，且这些影响归因于它们内源性转化为前列腺素。
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