豚鼠输精管的单脉冲刺激与突触前受体假说
Single pulse stimulation of guinea-pig vas deferens and the presynaptic receptor hypothesis.
作者信息
Kalsner S
出版信息
Br J Pharmacol. 1979 Jun;66(2):343-9. doi: 10.1111/j.1476-5381.1979.tb13686.x.
Abstract
1 The effect of phenoxybenzamine on the efflux of [3H]-noradrenaline and the mechanical response to single pulse excitation of superfused guinea-pig vas deferens was determined to examine the validity of the currently accepted hypothesis of a presynaptic negative feedback system on adrenergic nerve terminals. 2 The adrenoceptor antagonist enhanced both the outflow of tritium and the mechanical response to single pulse stimulation. The efflux of labelled material and the responses to 4 pulses were also enhanced, as expected. 3 Blockade of neuronal and extraneuronal uptake did not by itself increase nerve-induced outflow or the mechanical response nor dated within the framework of a hypothesis that proposes that the enhancement of response and tritium efflux by phenoxybenzamine results from blockade of a feedback system whereby noradrenaline released by previous impulses inhibits its own subsequent release.
摘要
- 测定了酚苄明对[3H]-去甲肾上腺素流出以及对灌流豚鼠输精管单脉冲刺激的机械反应的影响，以检验当前被广泛接受的关于肾上腺素能神经末梢突触前负反馈系统假说的有效性。2. 肾上腺素能受体拮抗剂增强了氚的流出以及对单脉冲刺激的机械反应。正如预期的那样，标记物质的流出以及对4个脉冲的反应也增强了。3. 神经元和非神经元摄取的阻断本身并不会增加神经诱导的流出或机械反应，也不符合这样一种假说框架，该假说认为酚苄明引起的反应增强和氚流出是由于反馈系统的阻断，即先前冲动释放的去甲肾上腺素抑制其随后的释放。
相似文献
1
Single pulse stimulation of guinea-pig vas deferens and the presynaptic receptor hypothesis.豚鼠输精管的单脉冲刺激与突触前受体假说
Br J Pharmacol. 1979 Jun;66(2):343-9. doi: 10.1111/j.1476-5381.1979.tb13686.x.
2
Evidence for autoinhibition of stimulation-induced noradrenaline release from vasa deferentia of the guinea-pig and rat.豚鼠和大鼠输精管刺激诱导去甲肾上腺素释放的自身抑制证据。
Br J Pharmacol. 1985 Oct;86(2):455-64. doi: 10.1111/j.1476-5381.1985.tb08915.x.
3
Adrenergic presynaptic receptors: examination of a hypothesis in guinea pig vas deferens.肾上腺素能突触前受体：豚鼠输精管中一种假说的研究
Can J Physiol Pharmacol. 1979 Jul;57(7):717-24. doi: 10.1139/y79-108.
4
5
Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens.家兔门静脉和输精管中肾上腺素能递质释放及失活调控机制的评估
Br J Pharmacol. 1972 Mar;44(3):472-91. doi: 10.1111/j.1476-5381.1972.tb07285.x.
6
Lack of correlation between profiles of transmitter efflux and of muscular contraction in response to nerve stimulation in isolated guinea-pig vas deferens.在离体豚鼠输精管中，递质外流情况与神经刺激引起的肌肉收缩情况之间缺乏相关性。
Acta Physiol Scand. 1973 May;88(1):137-44. doi: 10.1111/j.1748-1716.1973.tb05440.x.
7
Prostaglandin action on noradrenaline release and mechanical responses in the stimulated guinea pig vas deferens.前列腺素对刺激的豚鼠输精管中去甲肾上腺素释放及机械反应的作用
Acta Physiol Scand. 1974 Jan;90(1):86-93. doi: 10.1111/j.1748-1716.1974.tb05566.x.
8
Inhibition of post-ganglionic motor transmission in vas deferens by indirectly acting sympathomimetic drugs.间接作用拟交感神经药对输精管节后运动传递的抑制作用。
J Physiol. 1972 Dec;227(2):433-56. doi: 10.1113/jphysiol.1972.sp010041.
9
Effect of reserpine, phenoxybenzamine and cocaine on neuromuscular transmission in the vas deferens of the guinea pig.利血平、酚苄明和可卡因对豚鼠输精管神经肌肉传递的影响。
J Pharmacol Exp Ther. 1972 May;181(2):310-7.
10
A hypothesis to explain the presynaptic effects of adrenoceptor antagonists.一种解释肾上腺素能受体拮抗剂突触前效应的假说。
Br J Pharmacol. 1984 Jun;82(2):515-22. doi: 10.1111/j.1476-5381.1984.tb10788.x.
引用本文的文献
1
Corelease of noradrenaline and ATP by brief pulse trains in guinea-pig vas deferens.豚鼠输精管中短暂脉冲串引发去甲肾上腺素和三磷酸腺苷的共同释放。
Naunyn Schmiedebergs Arch Pharmacol. 1994 Aug;350(2):123-9. doi: 10.1007/BF00241085.
2
Proceedings of the British Pharmacological Society. 16--18th December, 1980.英国药理学会会议记录。1980年12月16日至18日。
Br J Pharmacol. 1981 May;73(1):175P-318P. doi: 10.1111/j.1476-5381.1981.tb16787.x.
3
Proceedings of the British Pharmacological Society. 5th-7th January, 1983. Abstracts.英国药理学会会议记录。1983年1月5日至7日。摘要
Br J Pharmacol. 1983 Mar;78 Suppl(Suppl):1P-187P.
4
Effect of age on the prejunctional alpha-adrenoceptor-mediated feedback in the heart of spontaneously hypertensive rats and normotensive Wistar Kyoto rats. Evidence for a physiological role of prejunctional alpha 2-adrenoceptors.年龄对自发性高血压大鼠和正常血压Wistar Kyoto大鼠心脏中节前α-肾上腺素能受体介导的反馈的影响。节前α2-肾上腺素能受体生理作用的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(1):33-6. doi: 10.1007/BF00498824.
5
Stimulation-evoked release of [3H]-noradrenaline by 1, 10 or 100 pulses and its modification through presynaptic alpha 2-adrenoceptors.1、10或100个脉冲刺激诱发的[3H] -去甲肾上腺素释放及其通过突触前α2 -肾上腺素能受体的调节。
Br J Pharmacol. 1983 Jan;78(1):221-31. doi: 10.1111/j.1476-5381.1983.tb09383.x.
6
The role of presynaptic alpha-adrenoceptors in the regulation of blood pressure in the conscious rabbit.突触前α-肾上腺素能受体在清醒兔血压调节中的作用。
Br J Pharmacol. 1982 Mar;75(3):417-24. doi: 10.1111/j.1476-5381.1982.tb09156.x.
7
Site(s) and ionic basis of alpha-autoinhibition and facilitation of "3H'noradrenaline secretion in guinea-pig vas deferens.豚鼠输精管中α-自身抑制及“3H”去甲肾上腺素分泌促进作用的位点及离子基础。
J Physiol. 1981 Mar;312:297-334. doi: 10.1113/jphysiol.1981.sp013630.
8
Further study of prerequisites for the enhancement by alpha-adrenoceptor antagonists of the release of noradrenaline.关于α-肾上腺素能受体拮抗剂增强去甲肾上腺素释放的前提条件的进一步研究。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Mar;325(3):240-6. doi: 10.1007/BF00495950.
9
Yohimbine and prolongation of stimulation pulse duration alter similarly 3H-transmitter efflux in heart: an alternative to the negative feedback hypothesis.育亨宾与刺激脉冲持续时间的延长对心脏中3H递质流出的影响类似：对负反馈假说的一种替代解释。
Br J Pharmacol. 1983 Aug;79(4):985-92. doi: 10.1111/j.1476-5381.1983.tb10545.x.
10
Experimental conditions required for the enhancement by alpha-adrenoceptor antagonists of noradrenaline release in the rabbit ear artery.α-肾上腺素能受体拮抗剂增强兔耳动脉去甲肾上腺素释放所需的实验条件。
Br J Pharmacol. 1983 Mar;78(3):543-51. doi: 10.1111/j.1476-5381.1983.tb08814.x.
本文引用的文献
1
THE EFFECT OF PHENOXYBENZAMINE AND OF TOLAZOLINE ON THE RESPONSE TO SYMPATHETIC STIMULATION.苯氧苄胺和妥拉唑啉对交感神经刺激反应的影响。
Br J Pharmacol Chemother. 1964 Jun;22(3):527-39. doi: 10.1111/j.1476-5381.1964.tb01707.x.
2
EFFECT OF COCAINE, PHENOXYBENZAMINE AND PHENTOLAMINE ON THE CATECHOLAMINE OUTPUT FROM SPLEEN AND ADRENAL MEDULLA.可卡因、酚苄明和酚妥拉明对脾脏及肾上腺髓质儿茶酚胺分泌量的影响
J Pharmacol Exp Ther. 1963 Oct;142:59-70.
3
The metabolism of (3H)noradrenaline released by electrical stimulation from the isolated nictitating membrane of the cat and from the vas deferens of the rat.通过电刺激从猫的离体瞬膜和大鼠的输精管释放的（3H）去甲肾上腺素的代谢。
J Physiol. 1970 Jul;208(3):515-46. doi: 10.1113/jphysiol.1970.sp009135.
4
Enhanced release of dopamine- -hydroxylase from sympathetic nerves by calcium and phenoxybenzamine and its reversal by prostaglandins.钙和酚苄明促使交感神经中多巴胺-β-羟化酶的释放增加，而前列腺素可使其释放逆转。
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2227-30. doi: 10.1073/pnas.68.9.2227.
5
Drug-induced changes in the release of ( 3 H)-noradrenaline from field stimulated rat iris.药物诱导的大鼠虹膜经场刺激后（3H）-去甲肾上腺素释放的变化
Br J Pharmacol. 1971 Sep;43(1):97-106. doi: 10.1111/j.1476-5381.1971.tb07160.x.
6
Lack of correlation between profiles of transmitter efflux and of muscular contraction in response to nerve stimulation in isolated guinea-pig vas deferens.在离体豚鼠输精管中，递质外流情况与神经刺激引起的肌肉收缩情况之间缺乏相关性。
Acta Physiol Scand. 1973 May;88(1):137-44. doi: 10.1111/j.1748-1716.1973.tb05440.x.
7
Inhibition of 3 H-noradrenaline release from sympathetic nerves of guinea-pig atria by a presynaptic -adrenoceptor mechanism.通过突触前α-肾上腺素能受体机制抑制豚鼠心房交感神经释放3H-去甲肾上腺素。
Br J Pharmacol. 1972 Nov;46(3):523P-524P.
8
Variation in noradrenaline output with changes in stimulus frequency and train length: role of different noradrenaline pools.去甲肾上腺素释放量随刺激频率和串长变化的差异：不同去甲肾上腺素池的作用
Br J Pharmacol. 1974 Jul;51(3):373-81. doi: 10.1111/j.1476-5381.1974.tb10672.x.
9
10
3 H-noradrenaline release and mechanical response in the field stimulated mouse vas deferens.3H-去甲肾上腺素在电场刺激的小鼠输精管中的释放及机械反应
Acta Physiol Scand Suppl. 1971;371:1-18. doi: 10.1111/j.1748-1716.1971.tb05210.x.
Zotero 插件