骨髓瘤中的脊髓压迫
Spinal-cord compression in myeloma.
作者信息
Benson W J, Scarffe J H, Todd I D, Palmer M, Crowther D
出版信息
Br Med J. 1979 Jun 9;1(6177):1541-4. doi: 10.1136/bmj.1.6177.1541.
Abstract
Clinical records of 47 patients in whom spinal-cord compression was the presenting feature of plasma-cell myeloma were analysed retrospectively. Patients were referred during 1954-78. Median survival was 30 months and prognosis was best for those in whom the site of cord compression was the thoracic region. Early laminectomy and decompression followed by adequate radiotherapy resulted in complete or good partial response in over a third of patients who presented with complete paraplegia. Improvements in supportive care and more effective chemotherapy allow spinal-cord compression in myeloma to be treated promptly and vigorously, thus improving duration and quality of survival in a substantial proportion of patients.
摘要
对47例以脊髓压迫为浆细胞骨髓瘤首发特征的患者的临床记录进行了回顾性分析。患者于1954年至1978年期间就诊。中位生存期为30个月，脊髓压迫部位在胸部的患者预后最佳。对于出现完全性截瘫的患者，早期椎板切除术和减压术，随后进行充分的放疗，使超过三分之一的患者获得了完全或良好的部分缓解。支持治疗的改善和更有效的化疗使得骨髓瘤脊髓压迫能够得到及时且积极的治疗，从而在相当比例的患者中提高了生存时间和生存质量。
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