Poller L, Thomson J M, Otridge B W, Yee K F, Logan S H
Br Med J. 1979 Jun 30;1(6180):1761-2. doi: 10.1136/bmj.1.6180.1761.
In monitoring the effects of industrial exposure resulting from the pharmaceutical manufacture of oestrogen-progestogen combinations by coagulation studies acceleration of some clotting tests was found. The most pronounced changes were in workers most closely associated with the industrial process. Less pronounced changes were found in women employees not closely concerned with the processing and may have been secondary to the postmenopausal bleeding to which they were prone. A safer work procedure elaborated by the Employment Medical Advisory Service was monitored by clotting studies for over a year but the three most highly exposed subjects showed no substantial improvement.
在通过凝血研究监测雌激素 - 孕激素组合药物制造过程中的工业暴露影响时，发现一些凝血试验加速。最明显的变化出现在与工业过程联系最紧密的工人身上。在与加工过程关系不紧密的女性员工中发现的变化不太明显，可能是她们易患的绝经后出血所致。就业医疗咨询服务机构制定的一种更安全的工作程序通过凝血研究监测了一年多，但三名暴露程度最高的受试者没有明显改善。
