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Interaction of prostaglandins with blood plasma proteins. Comparative binding of prostaglandins A 2 , F 2 and E 2 to human plasma proteins.前列腺素与血浆蛋白的相互作用。前列腺素A2、F2和E2与人血浆蛋白的结合比较。
Biochem J. 1972 Nov;130(2):631-6. doi: 10.1042/bj1300631.
2
Interaction of prostaglandins with blood plasma proteins. I. Binding of prostaglandin E 2 to human plasma proteins and its effect on the physiological activity of prostaglandin E 2 in vitro and in vivo.前列腺素与血浆蛋白的相互作用。I. 前列腺素E2与人血浆蛋白的结合及其对前列腺素E2体内外生理活性的影响。
Biochim Biophys Acta. 1972 Dec 8;280(4):602-13.
3
Prostaglandin-macromolecule interactions. I. Noncovalent binding of prostaglandins A1, E1, F2alpha, and E2 by human and bovine serum albumins.前列腺素与大分子的相互作用。I. 人血清白蛋白和牛血清白蛋白对前列腺素A1、E1、F2α和E2的非共价结合
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4
Interaction of prostaglandins with blood plasma proteins. 3. Rate of disappearance and metabolites formation after intravenous administration of free or albumin-bound prostaglandins F 2 and A 2 .前列腺素与血浆蛋白的相互作用。3. 静脉注射游离型或白蛋白结合型前列腺素F2和A2后其消失速率及代谢产物的形成
Life Sci II. 1972 Oct 8;11(19):965-74.
5
Binding of digitoxin and some related cardenolides to human plasma proteins.洋地黄毒苷及一些相关强心甾类与人体血浆蛋白的结合
J Clin Invest. 1969 Jun;48(6):1041-53. doi: 10.1172/JCI106060.
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Binding of prostaglandin to human serum albumin.前列腺素与人血清白蛋白的结合
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The effect of ligand presaturation on the interaction of serum albumins with an immobilized Cibacron Blue 3G-A studied by affinity gel electrophoresis.通过亲和凝胶电泳研究配体预饱和对血清白蛋白与固定化汽巴蓝3G - A相互作用的影响。
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Development and standardization of radioimmunoassays for prostaglandins E, F, and A.前列腺素E、F和A放射免疫分析方法的开发与标准化
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9
Metabolities formed after intravenous administration of free or albumin-bound prostaglandin E 2 in the rat.
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10
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Albumin Counteracts Immune-Suppressive Effects of Lipid Mediators in Patients With Advanced Liver Disease.白蛋白可拮抗晚期肝病患者脂质介质的免疫抑制作用。
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The distribution of prostaglandins in afferent and efferent lymph from inflammatory sites.前列腺素在来自炎症部位的输入淋巴管和输出淋巴管中的分布。
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Effect of sulphasalazine on pulmonary inactivation of prostaglandin F2 alpha in the pig.柳氮磺胺吡啶对猪体内前列腺素F2α肺灭活作用的影响。
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10
Effects of sulphasalazine and its metabolites on prostaglandin synthesis, inactivation and actions on smooth muscle.柳氮磺胺吡啶及其代谢产物对前列腺素合成、失活及对平滑肌作用的影响。
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本文引用的文献

1
PROSTAGLANDINS AND RELATED FACTORS. 27. SYNTHESIS OF TRITIUM-LABELED PROSTAGLANDIN E1 AND STUDIES ON ITS DISTRIBUTION AND EXCRETION IN THE RAT.前列腺素及相关因子。27. 氚标记前列腺素E1的合成及其在大鼠体内的分布与排泄研究。
J Biol Chem. 1964 Dec;239:4091-6.
2
Prostaglandins: their disappearance from and release into the circulation.前列腺素：它们在循环系统中的消失与释放
Nature. 1967 Dec 2;216(5118):868-73. doi: 10.1038/216868a0.
3
Selective passage of prostaglandins across the lung.前列腺素在肺中的选择性转运。
Nature. 1969 Aug 16;223(5207):742-5. doi: 10.1038/223742b0.
4
Binding of long-chain fatty acids to bovine serum albumin.长链脂肪酸与牛血清白蛋白的结合
J Lipid Res. 1969 Jan;10(1):56-67.
5
Metabolism of prostaglandin E2 in the rat.
Biochemistry. 1971 Mar 16;10(6):1072-86. doi: 10.1021/bi00782a022.
6
Prostaglandins A1,A2 and 19-hydroxy A1; their actions on smooth muscle and their inactivation on passage through the pulmonary and hepatic portal vascular beds.前列腺素A1、A2和19-羟基A1；它们对平滑肌的作用以及在通过肺和肝门静脉血管床时的失活。
Br J Pharmacol. 1969 Nov;37(3):705-22. doi: 10.1111/j.1476-5381.1969.tb08509.x.
7
The metabolism of prostaglandin F2-alpha in the rat.大鼠体内前列腺素F2-α的代谢
Biochim Biophys Acta. 1971 May 4;231(3):419-44.
8
The interaction of thyroxine with human plasma prealbumin and with the prealbumin-retinol-binding protein complex.甲状腺素与人类血浆前白蛋白以及前白蛋白 - 视黄醇结合蛋白复合物的相互作用。
J Biol Chem. 1969 Jun 25;244(12):3230-7.

前列腺素与血浆蛋白的相互作用。前列腺素A2、F2和E2与人血浆蛋白的结合比较。

Interaction of prostaglandins with blood plasma proteins. Comparative binding of prostaglandins A 2 , F 2 and E 2 to human plasma proteins.

作者信息

Raz A

出版信息

Biochem J. 1972 Nov;130(2):631-6. doi: 10.1042/bj1300631.

DOI:10.1042/bj1300631
PMID:4664590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1174443/
Abstract
  1. The binding of prostaglandin A(2) and prostaglandin F(2alpha) to human plasma proteins was investigated by DEAE-Sephadex chromatography and polyacrylamide-gel electrophoresis. Both prostaglandins, when added to human plasma in vitro, were found to become bound mainly to plasma albumin. 2. The extent of binding of prostaglandins added to human plasma in low to moderate concentrations was found to be approx. 88, 73 and 58% for prostaglandins A(2), E(2) and F(2alpha) respectively. The order of affinities for the binding of the three prostaglandins to albumin appear to be A(2)>E(2)>F(2alpha). 3. The apparent association constants for the binding of these prostaglandins to human serum albumin were estimated to be approx. 4.8x10(4), 2.4x10(4) and 0.9x10(4) litre/mol for prostaglandins A(2), E(2) and F(2alpha) respectively. The results are compared with previously reported association constants for the binding of long-chain fatty acids to both human and bovine albumins.
摘要
  1. 通过二乙氨基乙基葡聚糖凝胶（DEAE - Sephadex）柱色谱法和聚丙烯酰胺凝胶电泳法研究了前列腺素A(2)和前列腺素F(2α)与人血浆蛋白的结合情况。当在体外将这两种前列腺素添加到人血浆中时，发现它们主要与血浆白蛋白结合。2. 发现以低至中等浓度添加到人血浆中的前列腺素的结合程度分别约为：前列腺素A(2)为88%，前列腺素E(2)为73%，前列腺素F(2α)为58%。这三种前列腺素与白蛋白结合的亲和力顺序似乎是A(2)>E(2)>F(2α)。3. 这些前列腺素与人血清白蛋白结合的表观缔合常数估计分别约为：前列腺素A(2)为4.8×10⁴升/摩尔，前列腺素E(2)为2.4×10⁴升/摩尔，前列腺素F(2α)为0.9×10⁴升/摩尔。将这些结果与先前报道的长链脂肪酸与人及牛白蛋白结合的缔合常数进行了比较。