Thody A J, de Rotte A A, van Wimersma Greidanus T J
Brain Res Bull. 1979 Mar-Apr;4(2):213-6. doi: 10.1016/0361-9230(79)90284-3.
Immunoreactive alpha-MSH was measured in cerebrospinal fluid (CSF) and plasma of rats. While treatment with haloperidol increased alpha-MSH levels in the plasma concentration of alpha-MSH in the CSF showed little change. Hypophysectomy also had little effect on the concentration of alpha-MSH in the CSF despite the fall in plasma alpha-MSH levels. This lack of correlation between alpha-MSH levels in the CSF and plasma suggests that the systemic circulation does not deliver alpha-MSH to the CSF. The apparently normal levels of alpha-MSH in the hypothalamus after hypophysectomy suggests that this tissue is able to synthesize alpha-MSH and it is possible that the hypothalamus is a source of the alpha-MSH in the CSF.
在大鼠的脑脊液（CSF）和血浆中检测了免疫反应性α-促黑素（alpha-MSH）。虽然用氟哌啶醇治疗可使血浆中α-促黑素水平升高，但脑脊液中α-促黑素的血浆浓度变化不大。垂体切除术对脑脊液中α-促黑素的浓度也几乎没有影响，尽管血浆中α-促黑素水平有所下降。脑脊液和血浆中α-促黑素水平之间缺乏相关性，这表明体循环不会将α-促黑素输送到脑脊液中。垂体切除术后下丘脑α-促黑素水平明显正常，这表明该组织能够合成α-促黑素，并且下丘脑有可能是脑脊液中α-促黑素的来源。
