Borkar A, DaCosta H
Clin Nucl Med. 1979 Jul;4(7):294-5. doi: 10.1097/00003072-197907000-00009.
The integrity of the blood-brain barrier may be reflected by the blood and cerebrospinal fluid (CSF) if these two compartments are sampled at an appropriate interval after the administration of certain substances. After reading through the controversial literature, this study was undertaken to determine the frequency with which 99mTc-sodium pertechnetate entered the CSF to an abnormal extent, and to see whether this was related to any particular pathology. The plasma-to-CSF ratios were determined in 51 patients 4 hours following the intravenous administration of 0.5-10 mCi 99mTc-sodium pertechnetate. In 23 patients with active CNS tuberculosis, the mean value of the pertechnetate plasma-to-CSF ration was 32.12. In contradistinction, the plasma-to-CSF pertechnetate in 28 nontuberculous subjects was considerably higher (144.63). For the purpose of correlation, a 82Br partition test was also done on each subject 48 hours following the oral administration of NH82Br. The 48-hour study in each of these cases was generally in agreement with the pertechnetate studies: the plasma-to-CSF ratio mean value was 1.25 in patients with active CNS tuberculosis, while for the nontuberculous patients it was 3.32.
如果在给予某些物质后的适当时间间隔对血液和脑脊液（CSF）进行采样，血脑屏障的完整性可能会通过血液和脑脊液反映出来。在研读了有争议的文献后，开展了本研究，以确定高锝[99mTc]酸钠异常进入脑脊液的频率，并观察这是否与任何特定病理情况相关。在静脉注射0.5 - 10毫居里高锝[99mTc]酸钠4小时后，测定了51例患者的血浆与脑脊液的比值。在23例活动性中枢神经系统结核患者中，高锝酸盐血浆与脑脊液比值的平均值为32.12。相比之下，28例非结核患者的血浆与脑脊液高锝酸盐比值则高得多（144.63）。为了进行相关性分析，在口服NH82Br 48小时后，还对每个受试者进行了82Br分配试验。这些病例中每例的48小时研究结果通常与高锝酸盐研究结果一致：活动性中枢神经系统结核患者的血浆与脑脊液比值平均值为1.25，而非结核患者为3.32。
