Moyses B, Weitzenblum E, Methlin G
Clin Nucl Med. 1979 Aug;4(8):345-52. doi: 10.1097/00003072-197908000-00011.
Studies of regional lung function have developed rapidly in the last few years. Xenon -133 is the most frequently used isotope because of its physiocochemical and biologic properties. Fixed counters are being replaced by the scintillation camera interfaced to a computer allowing easy acquisition and interpretation of results and numerical data. The use of isotopes other than 133Xe, such as 81mKr, is less widespread. In this article, a method is described for studying regional ventilation in which the isotope used is 133Xe, the radioactivity is recorded by a scintillation camera, interfaced to a computer andsix (or 12) regions for both lungs are selected and investigated. The regional ventilation is expressed as an absolute value in ml/min/ml of ventilated volume as well as the relative contribution in percent of each zone to the total ventilation and volume. To illustrate this method, the results are reported for healthy subjects and for patients with chronic bronchitis and emphysema. Scintigraphs of individual cases are presented. Certain theoretic problems related to calculation of regional ventilation are discussed.
近年来，区域肺功能研究发展迅速。由于其物理化学和生物学特性，氙-133是最常用的同位素。固定计数器正被与计算机相连的闪烁照相机所取代，这使得结果和数值数据的获取与解读变得容易。除133Xe之外的其他同位素，如81mKr的使用则不太广泛。在本文中，描述了一种研究区域通气的方法，其中使用的同位素是133Xe，放射性由与计算机相连的闪烁照相机记录，选取并研究双肺的六个（或十二个）区域。区域通气以每毫升通气量的毫升/分钟绝对值表示，以及每个区域对总通气和容积的相对贡献百分比表示。为说明该方法，报告了健康受试者以及慢性支气管炎和肺气肿患者的结果。展示了个别病例的闪烁扫描图。讨论了与区域通气计算相关的某些理论问题。
