Fahmy N R, Malek N S, Lappas D G
Clin Pharmacol Ther. 1979 Sep;26(3):395-8. doi: 10.1002/cpt1979263395.
Neuromuscular, circulatory, and adverse effects of intravenous succinylcholine (SCh), mg/kg, were compared in 3 groups of 40 patients each. Group I served as control; group II received diazepam, 0.05 mg/kg, 5 min before SCh; and group III was given d-tubocurarine (d-Tc), 0.05 mg/kg, for pretreatment. Diazepam pretreatment prevented muscle fasciculations, increases in serum potassium (K+) and creatinine phosphokinase (CPK) levels, increased heart rate and arterial pressure, and postoperative myalgia associated with SCh administration. The neuromuscular blocking action of SCh was not affected. Pretreatment with d-Tc did not abolish increases in serum K+ and CPK levels, was associated with a higher incidence of postoperative myalgia, and decreased the onset and magnitude of SCh-induced muscle paralysis. Our data demonstrate that diazepam, a predominant centrally acting muscle relaxant, is more effective than d-Tc in preventing the adverse effects of SCh, a peripherally acting muscle relaxant.
将每组40例患者分为3组，比较静脉注射琥珀酰胆碱（SCh），mg/kg，对神经肌肉、循环系统的影响以及不良反应。第一组作为对照组；第二组在注射SCh前5分钟给予地西泮，0.05mg/kg；第三组给予右旋筒箭毒碱（d-Tc），0.05mg/kg，进行预处理。地西泮预处理可预防肌肉震颤、血清钾（K+）和肌酸磷酸激酶（CPK）水平升高、心率和动脉压升高以及与SCh给药相关的术后肌痛。SCh的神经肌肉阻滞作用不受影响。d-Tc预处理并未消除血清K+和CPK水平的升高，与术后肌痛的发生率较高相关，并降低了SCh诱导的肌肉麻痹的起效时间和程度。我们的数据表明，作为主要中枢性肌肉松弛剂的地西泮，在预防外周性肌肉松弛剂SCh的不良反应方面比d-Tc更有效。
