Kumar Mahendra, Talwar Nalin, Goyal Ritu, Shukla Usha, Sethi Ak
Department of Anaesthesiology and Critical Care, University College of Medical Sciences and GTB Hospital, Shahdara, Delhi, India.
J Anaesthesiol Clin Pharmacol. 2012 Jan;28(1):81-5. doi: 10.4103/0970-9185.92451.
Magnesium sulfate and propofol have been found to be effective against succinylcholine-induced fasciculations and myalgia, respectively, in separate studies. A prospective randomized double blind controlled study was designed to assess the effect of a combination of magnesium sulfate with propofol for induction of anesthesia on succinylcholine-induced fasciculations and myalgia.
Randomly selected 60 adult patients scheduled for elective surgery under general anesthesia were allocated to one of the two equal groups by draw of lots. The patients of MG Group were pretreated with magnesium sulfate 40 mg/kg body weight in 10 ml volume, while patients of NS group were given isotonic saline 0.9% in the same volume (10 ml) intravenously slowly over a period of 10 min. Anesthesia was induced with fentanyl 1.5 mcg/kg and propofol 2 mg/kg, followed by administration of succinylcholine 2 mg/kg intravenously. Muscle fasciculations were observed and graded as nil, mild, moderate, or severe. Postoperative myalgia was assessed after 24 h of surgery and graded as nil, mild, moderate, or severe. Observations were made in double blind manner.
Demographic data of both groups were comparable (P > 0.05). Muscle fasciculations occurred in 50% patients of MG group versus in 100% patients of NS group with a significant difference (P < 0.001). After 24 h of surgery, no patient of MG group and 30% patients of NS group had myalgia with a significant difference (P < 0.002).
Magnesium sulfate 40 mg/kg intravenously may be used with propofol for induction of anesthesia to control succinylcholine-induced fasciculations and myalgia.
在单独的研究中，已发现硫酸镁和丙泊酚分别对琥珀酰胆碱诱导的肌束震颤和肌痛有效。本前瞻性随机双盲对照研究旨在评估硫酸镁与丙泊酚联合用于麻醉诱导对琥珀酰胆碱诱导的肌束震颤和肌痛的影响。
随机选取60例计划在全身麻醉下接受择期手术的成年患者，通过抽签将其分为两组，每组人数相等。MG组患者静脉缓慢注射10ml含40mg/kg体重硫酸镁的溶液进行预处理，而NS组患者静脉缓慢注射相同体积（10ml）的0.9%等渗盐水。静脉注射芬太尼1.5mcg/kg和丙泊酚2mg/kg诱导麻醉，随后静脉注射琥珀酰胆碱2mg/kg。观察肌束震颤并分为无、轻度、中度或重度。术后24小时评估术后肌痛并分为无、轻度、中度或重度。观察采用双盲方式进行。
两组的人口统计学数据具有可比性（P>0.05）。MG组50%的患者出现肌束震颤，而NS组100%的患者出现肌束震颤，差异有统计学意义（P<0.001）。术后24小时，MG组无患者出现肌痛，而NS组30%的患者出现肌痛，差异有统计学意义（P<0.002）。
静脉注射40mg/kg硫酸镁可与丙泊酚联合用于麻醉诱导，以控制琥珀酰胆碱诱导的肌束震颤和肌痛。
