缺乏C1-C2氮丙啶环的丝裂霉素相关化合物的抑制作用。
Inhibitory effects of mitomycin-related compounds lacking the C1-C2 aziridine ring.
作者信息
Mercado C M, Tomasz M
出版信息
Antimicrob Agents Chemother. 1972 Jan;1(1):73-7. doi: 10.1128/AAC.1.1.73.
Abstract
Three chemical derivatives of mitomycin C cause loss of viability, inhibition of deoxyribonucleic acid synthesis, and inhibition of cell division in bacteria. Each of these drugs lacks the C(1)-C(2) aziridine ring previously postulated to be essential for the bactericidal effect of mitomycin C.
摘要
丝裂霉素C的三种化学衍生物可导致细菌活力丧失、脱氧核糖核酸合成受到抑制以及细胞分裂受到抑制。这些药物中的每一种都缺乏先前假定对丝裂霉素C的杀菌作用至关重要的C(1)-C(2)氮丙啶环。
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