Kivinen S, Tarkkila T, Laakso L, Laakso K
Curr Med Res Opin. 1979;6(2):88-92. doi: 10.1185/03007997909109403.
A combination of 5-fluorocytosine (1000 mg) and candicidin (5 mg) was compared with clotrimazole (100 mg) in the treatment of 112 non-pregnant volunteers with vulvovaginal candidiasis. Seventy-two (75%) of the 96 patients treated with 1 or 2 vaginal tablets of the combination product and 10 (62%) of the 16 women treated with clotrimazole for 6 days were cured. The efficacy of the treatments was assessed mycologically and clinically 1 week and 1 month after the therapy. Both treatments were well tolerated and no side-effects could be detected. It is concluded that a short-term vaginal treatment with a 5-fluorocytosine and candicidin combination is effective in vaginal moniliasis, and the brevity of the treatment is an advantage compared with others now available.
将5-氟胞嘧啶（1000毫克）和杀假丝菌素（5毫克）的组合与克霉唑（100毫克）进行比较，用于治疗112名患有外阴阴道念珠菌病的非妊娠志愿者。用该组合产品的1或2片阴道片治疗的96名患者中有72名（75%）治愈，用克霉唑治疗6天的16名女性中有10名（62%）治愈。在治疗后1周和1个月从真菌学和临床方面评估治疗效果。两种治疗耐受性良好，未检测到副作用。得出结论，5-氟胞嘧啶和杀假丝菌素组合的短期阴道治疗对阴道念珠菌病有效，与现有的其他治疗相比，治疗时间短是一个优点。
