安非他命与条件性“焦虑”。

Amphetamine and conditioned 'anxiety'.

作者信息

Cappell H, Ginsberg R, Webster C D

出版信息

Br J Pharmacol. 1972 Jul;45(3):525-31. doi: 10.1111/j.1476-5381.1972.tb08110.x.

DOI:10.1111/j.1476-5381.1972.tb08110.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666153/

Abstract

Rats pressed a bar for milk reward at a steady rate, but this baseline responding was suppressed in the presence of an auditory stimulus associated with electric shock (conditioned suppression). The effects of (+)-amphetamine sulphate on this conditioned suppression were studied in two experiments.2. (+)-Amphetamine sulphate (0.5, 1.0 or 2.0 mg/kg) reduced the baseline rate of responding and also reduced the conditioned suppression, i.e. responding in the presence of the auditory stimulus was partially restored. Both these effects were dose related.3. In a further experiment the effects of 1.0 mg/kg on two levels of conditioned suppression were studied. Regardless of its degree, (+)-amphetamine attenuated suppression.4. The results were compared to previous research which found that amphetamine increased baseline responding and exaggerated conditioned suppression. It was concluded that the conditioned suppression procedure should be used with caution as an animal model of anxiety in psychopharmacological investigations.

摘要

大鼠以稳定的速率按压杠杆以获取牛奶奖励，但在与电击相关的听觉刺激出现时（条件性抑制），这种基线反应会受到抑制。在两项实验中研究了硫酸右苯丙胺对这种条件性抑制的影响。
硫酸右苯丙胺（0.5、1.0或2.0毫克/千克）降低了基线反应速率，也减轻了条件性抑制，即听觉刺激出现时的反应部分恢复。这两种效应都与剂量相关。
在进一步的实验中，研究了1.0毫克/千克对两种条件性抑制水平的影响。无论抑制程度如何，硫酸右苯丙胺都能减轻抑制。
将结果与之前的研究进行了比较，之前的研究发现苯丙胺会增加基线反应并夸大条件性抑制。得出的结论是，在精神药理学研究中，作为焦虑症动物模型的条件性抑制程序应谨慎使用。