Morita R, Yamamoto I, Fukunaga M, Dokoh S, Konishi J, Kousaka T, Nakajima K, Torizuka K, Aso T, Motohashi T
Endocrinol Jpn. 1979 Jun;26(Suppl):15-22. doi: 10.1507/endocrj1954.26.supplement_15.
Measurement of bone mineral content (BMC), intestinal 47Ca absorption, and calcium regulating hormones and sex steroids in serum were performed on 32 healthy aged subjects and 26 control young subjects. In BMC, there was a progressive fall after age 40, with the rate of decrease being greater in women than in men. A significant correlation was observed between BMC and testosterone in the men and between estrogens and BMC in the women, suggesting the possible importance of testosterone in men and estrogens in women in maintaining bone mass. Plasma PTH showed no change with age. However, the reserve capacity of the parathyroid was significantly reduced in the aged women. Serum levels of ionized calcium were low in aged subjects, indicating a possible alteration with age in the feedback control between ionized calcium levels and parathyroid hormone secretion. C-cell funtion was also decreased with age. Plasma 1,25-(OH)2D and 47Ca absorption tended to decrease with age. Age-related bone loss could be a reflection of the interaction of these hormonal imbalance occurring with age.
对32名健康老年受试者和26名对照年轻受试者进行了骨矿物质含量（BMC）、肠道47Ca吸收以及血清中钙调节激素和性类固醇的测量。在BMC方面，40岁以后呈逐渐下降趋势，女性下降速率大于男性。男性中观察到BMC与睾酮之间以及女性中雌激素与BMC之间存在显著相关性，这表明睾酮对男性和雌激素对女性在维持骨量方面可能具有重要作用。血浆甲状旁腺激素（PTH）水平不随年龄变化。然而，老年女性甲状旁腺的储备能力显著降低。老年受试者血清离子钙水平较低，表明离子钙水平与甲状旁腺激素分泌之间的反馈控制可能随年龄发生改变。C细胞功能也随年龄下降。血浆1,25 - (OH)2D和47Ca吸收倾向于随年龄降低。与年龄相关的骨质流失可能反映了随着年龄增长这些激素失衡之间的相互作用。
