In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine.
作者信息
Frigerio A, Negrini P, Cappellini L, Rotilio D, De Pascale A, Rossi E
出版信息
Eur J Drug Metab Pharmacokinet. 1979;4(1):35-41. doi: 10.1007/BF03189397.
PMID:467466
Abstract
Dibenzo [c,f]-[1,2] diazepine is a new compound with a tricyclic structure and a double bond between two nitrogen atoms in positions 1 and 2 of the molecule. Its in vitro metabolism has been studied, incubating the compound with rat liver microsomes. Two metabolites have been identified: dibenzo [c,f] - [1,2]diazepine-1-N-oxide and a monohydroxyderivative in the aromatic ring.
摘要
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