吲哚美辛的经皮渗透
Percutaneous penetration of indomethacin.
作者信息
Ishihama H, Kimata H, Mizushima Y
出版信息
Experientia. 1979 Jun 15;35(6):798-9. doi: 10.1007/BF01968257.
PMID:467596
Abstract
14C-Indomethacin (ID) was applied to the skin of guinea-pigs as an ointment. After several applications, the concentration of ID in the skin and muscle under the applied site reached a constant level. The concentration of ID in the muscle as well as the skin may be enough to exert an anti-inflammatory effect.
摘要
将14C-吲哚美辛（ID）制成软膏涂抹于豚鼠皮肤。多次涂抹后，涂抹部位下方皮肤和肌肉中的ID浓度达到稳定水平。肌肉和皮肤中的ID浓度可能足以发挥抗炎作用。
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