• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

吲哚美辛的经皮渗透

Percutaneous penetration of indomethacin.

作者信息

Ishihama H, Kimata H, Mizushima Y

出版信息

Experientia. 1979 Jun 15;35(6):798-9. doi: 10.1007/BF01968257.

DOI:10.1007/BF01968257
PMID:467596
Abstract

14C-Indomethacin (ID) was applied to the skin of guinea-pigs as an ointment. After several applications, the concentration of ID in the skin and muscle under the applied site reached a constant level. The concentration of ID in the muscle as well as the skin may be enough to exert an anti-inflammatory effect.

摘要

将14C-吲哚美辛(ID)制成软膏涂抹于豚鼠皮肤。多次涂抹后,涂抹部位下方皮肤和肌肉中的ID浓度达到稳定水平。肌肉和皮肤中的ID浓度可能足以发挥抗炎作用。

相似文献

1
Percutaneous penetration of indomethacin.吲哚美辛的经皮渗透
Experientia. 1979 Jun 15;35(6):798-9. doi: 10.1007/BF01968257.
2
[Evaluation of nonsteroidal anti-inflammatory drugs (NSAID) intended for use as topical anti-inflammatory drugs].[用于局部抗炎药物的非甾体抗炎药(NSAID)的评估]
Nihon Yakurigaku Zasshi. 1982 Jun;79(6):461-85.
3
Effect of bases and accelerants on the anti-inflammatory activity of topical corticosteroids.
Dermatologica. 1976;152 Suppl 1:81-9. doi: 10.1159/000257868.
4
[Percutaneous absorption of diflucortolone valerate in guinea pigs and man (author's transl)].戊酸二氟可的龙在豚鼠和人体中的经皮吸收(作者译)
Arzneimittelforschung. 1976;26(7b):1479-84.
5
Anti-inflammatory activity of ointments of indomethacin and its calcium salt applied to abdominal skin of rat.吲哚美辛及其钙盐软膏对大鼠腹部皮肤的抗炎活性
Chem Pharm Bull (Tokyo). 1988 Feb;36(2):757-62. doi: 10.1248/cpb.36.757.
6
Topical therapies for rheumatoid arthritis by gel ointments containing indomethacin nanoparticles in adjuvant-induced arthritis rat.含吲哚美辛纳米颗粒的凝胶软膏对佐剂诱导性关节炎大鼠类风湿性关节炎的局部治疗
J Oleo Sci. 2015;64(3):337-46. doi: 10.5650/jos.ess14170. Epub 2015 Feb 9.
7
Percutaneous absorption and anti-inflammatory activity of indomethacin in ointment.
J Pharm Pharmacol. 1982 Jul;34(7):467-8. doi: 10.1111/j.2042-7158.1982.tb04763.x.
8
[Anti-inflammatory and analgesic activities of a trans-cutaneous non-steroidal anti-inflammatory agent, etofenamate gel].[一种经皮非甾体抗炎药依托芬那酯凝胶的抗炎和镇痛活性]
Nihon Yakurigaku Zasshi. 1982 Aug;80(2):183-94.
9
Polycaprolactone Based Nanoparticles Loaded with Indomethacin for Anti-Inflammatory Therapy: From Preparation to Ex Vivo Study.负载吲哚美辛的聚己内酯基纳米颗粒用于抗炎治疗:从制备到体外研究
Pharm Res. 2017 Sep;34(9):1773-1783. doi: 10.1007/s11095-017-2166-7. Epub 2017 May 19.
10
Experimental evidence for amide hydrolysis of indomethacin in rabbit skin.吲哚美辛在兔皮肤中酰胺水解的实验证据。
Skin Pharmacol. 1990;3(1):41-4. doi: 10.1159/000210839.

引用本文的文献

1
A physiological pharmacokinetic model for solute disposition in tissues below a topical below a topical application site.一种用于局部应用部位以下组织中溶质处置的生理药代动力学模型。
Pharm Res. 1999 Sep;16(9):1392-8. doi: 10.1023/a:1018998908655.
2
Topical NSAIDs for musculoskeletal conditions. A review of the literature.用于肌肉骨骼疾病的外用非甾体抗炎药。文献综述。
Drugs. 1998 Nov;56(5):783-99. doi: 10.2165/00003495-199856050-00004.

本文引用的文献

1
Physiologic disposition and metabolic fate of indomethacin analogs. I. 1-p-chlorobenzylidenyl-5-methoxy-2-methylindene-3-acetic acid.吲哚美辛类似物的生理处置与代谢命运。I. 1-对氯亚苄基-5-甲氧基-2-甲基茚-3-乙酸
J Pharm Sci. 1971 Jul;60(7):1049-52. doi: 10.1002/jps.2600600710.
2
Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid.吲哚美辛在血清和滑液中的同步药代动力学。
Ann Rheum Dis. 1973 Sep;32(5):433-5. doi: 10.1136/ard.32.5.433.