Mazzei M, Roma G, Ermili A, Cacciatore C
Farmaco Sci. 1979 Jun;34(6):469-77.
Treatment of N-alkylanilines or diphenylamine with N,N-dialkylethoxycarbonylacetamides in the presence of phosphorus oxychloride afforded 6-alkyl(phenyl)-4-dialkylaminopyrano [3,2-c] quinoline-2,5-(6H)-diones, two molecules of amide being involved in the reaction. In some instances 6-alkyl(phenyl)-4-alkylaminopyrano [3,2-c] quinoline-2,5(6H)-diones were obtained through a partial dealkylation of the amino group. Pharmacological evaluation of some compounds showed no activity on the CNS.
在三氯氧磷存在下，用N,N-二烷基乙氧羰基乙酰胺处理N-烷基苯胺或二苯胺，得到6-烷基（苯基）-4-二烷基氨基吡喃并[3,2-c]喹啉-2,5-（6H）-二酮，反应中涉及两分子酰胺。在某些情况下，通过氨基的部分脱烷基化得到6-烷基（苯基）-4-烷基氨基吡喃并[3,2-c]喹啉-2,5（6H）-二酮。对一些化合物的药理评价显示其对中枢神经系统无活性。
