轴突慢速运输或蛋白质；通过中断细胞体与轴突之间的接触来阻断。

Slow axonal transport or proteins; blockade by interruption of contact between cell body and axon.

作者信息

Frizell M, McLean W G, Sjöstrand J

出版信息

Brain Res. 1975 Mar 14;86(1):67-73. doi: 10.1016/0006-8993(75)90638-1.

Abstract

The influence of ligation and colchicine treatment on the axonal transport of slowly migrating [3H]leucine-labelled proteins was studied in the vagus nerve of the rabbit. Two days after [3H]leucine labelling of the dorsal motor nucleus of the vagus nerve, ligation or local application of 60 mM colchicine immediately blocked the further progression of slowly migrating proteins distal to the site of treatment. Application of 50-100 mug colchicine to the nerve cell bodies 2 days after labelling blocked the transport of slowly migrating proteins within the next 24 h. It is suggested that contact between nerve cell body and the axon is necessary for the maintenance of the slow transport of proteins in these nerves.

摘要

在兔迷走神经中研究了结扎和秋水仙碱处理对缓慢迁移的[³H]亮氨酸标记蛋白轴突运输的影响。用[³H]亮氨酸标记迷走神经背运动核两天后，结扎或局部应用60 mM秋水仙碱立即阻断了处理部位远端缓慢迁移蛋白的进一步前行。标记两天后向神经细胞体应用50 - 100μg秋水仙碱在接下来的24小时内阻断了缓慢迁移蛋白的运输。提示神经细胞体与轴突之间的接触对于维持这些神经中蛋白的慢速运输是必要的。