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雌激素在体内垂体水平对催乳素释放的抗多巴胺能活性。

Antidopaminergic activity of estrogens on prolactin release at the pituitary level in vivo.

作者信息

Ferland L, Labrie F, Euvrard C, Raynaud J P

出版信息

Mol Cell Endocrinol. 1979 Jun;14(3):199-204. doi: 10.1016/0303-7207(79)90045-5.

DOI:10.1016/0303-7207(79)90045-5
PMID:467781
Abstract

Treatment of female or male rats with estradiol benzoate led to an almost complete reversal of the inhibitory effect of low doses of dopamine on prolactin secretion. These data indicate that estrogens which have previously been shown to exert a potent antidopaminergic activity on prolactin secretion in anterior pituitary cells in primary culture have similar effects in vivo.

摘要

用苯甲酸雌二醇处理雌性或雄性大鼠,导致低剂量多巴胺对催乳素分泌的抑制作用几乎完全逆转。这些数据表明,先前已证实在原代培养中对垂体前叶细胞催乳素分泌具有强大抗多巴胺能活性的雌激素,在体内也有类似作用。

相似文献

1
Antidopaminergic activity of estrogens on prolactin release at the pituitary level in vivo.雌激素在体内垂体水平对催乳素释放的抗多巴胺能活性。
Mol Cell Endocrinol. 1979 Jun;14(3):199-204. doi: 10.1016/0303-7207(79)90045-5.
2
Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release.
Science. 1978 Jun 9;200(4346):1173-5. doi: 10.1126/science.418505.
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Estrogen alters the responsiveness of the anterior pituitary gland to the actions of dopamine on lysosomal enzyme activity and prolactin release.
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[Specific role of sex steroids on the pituitary level. Sex steroids and anterior pituitary secretion].[性类固醇在垂体水平的特定作用。性类固醇与垂体前叶分泌]
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Does dopamine inhibit or stimulate prolactin release in vitro? The effects of dopamine concentration and duration of in vivo estradiol treatment.多巴胺在体外是抑制还是刺激催乳素释放?多巴胺浓度和体内雌二醇治疗持续时间的影响。
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引用本文的文献

1
Intraventricular administration of estradiol modulates rat prolactin secretion and synthesis.脑室内给予雌二醇可调节大鼠催乳素的分泌与合成。
J Endocrinol Invest. 1996 Oct;19(9):586-92. doi: 10.1007/BF03349022.
2
The interaction between mediobasohypothalamic dopaminergic and endorphinergic neuronal systems as a key regulator of reproduction: an hypothesis.下丘脑内侧基底部多巴胺能与内啡肽能神经元系统之间的相互作用作为生殖的关键调节因素:一种假说。
J Endocrinol Invest. 1991 Apr;14(4):323-52. doi: 10.1007/BF03346826.