Kim C, Choi H, Kim C C, Kim J K, Kim M S, Park H J, Ahn B T
Electroencephalogr Clin Neurophysiol. 1975 Mar;38(3):235-43. doi: 10.1016/0013-4694(75)90244-8.
The study was planned to see if the hippocampus has an influence on fast wave sleep (FWS) as well as on slow wave sleep (SWS). From 8 male cats EEG, EMG and EOG were recorded for 24 h, first under normal conditions, secondly after cortical damage to the dorsal marginal portion of posterior ectosylvian gyrus, and thirdly following hippocampectomy done through the cortical damage. From the records, SWS, FWS and the sleep state (defined as a sequence of SWS or SWS-FWS phases between two successive waking states) were measured in terms of their occurrence, the mean duration and the total time they occupied in the day, night and 24 h. In addition, sleep sequences were classified according to the number of constituent sleep phases. Cortical damage did not affect SWS, FWS, or sleep state with regard to their occurrence, the mean duration, and the total time they occupied in 24 h. Nor did it affect the proportion of short and long sequences. The circadian variation of sleep was clearly retained. Hippocampectomy significantly reduced the total time occupied by sleep state, SWS and FWS, increased the occurrence of sleep state and SWS phase against decreased incidence of FWS phase, and reduced the mean duration of sleep state and SWS phase. Hippocampectomy also significantly increased the occurrence of sleep sequences with only one SWS phase at the cost of sequences with alternating SWS and FWS phases. Following hippocampectomy, the circadian variation of sleep was not only retained, but actually exagerated. The hippocampus in inferred to facilitate the FWS as well as the SWS phase of sleep.
该研究旨在探究海马体是否对快速眼动睡眠（FWS）以及慢波睡眠（SWS）有影响。对8只雄性猫的脑电图（EEG）、肌电图（EMG）和眼电图（EOG）进行了24小时记录，首先在正常条件下，其次是在对后外侧薛氏回背侧边缘部分进行皮质损伤后，最后是通过皮质损伤进行海马切除术后。从记录中，测量了慢波睡眠、快速眼动睡眠和睡眠状态（定义为两个连续清醒状态之间的慢波睡眠或慢波睡眠 - 快速眼动睡眠阶段序列）的出现情况、平均持续时间以及它们在白天、夜晚和24小时内所占的总时间。此外，根据组成睡眠阶段的数量对睡眠序列进行了分类。皮质损伤在慢波睡眠、快速眼动睡眠或睡眠状态的出现情况、平均持续时间以及它们在24小时内所占的总时间方面均未产生影响。它也没有影响短序列和长序列的比例。睡眠的昼夜变化明显保留。海马切除术后，显著减少了睡眠状态、慢波睡眠和快速眼动睡眠所占的总时间，增加了睡眠状态和慢波睡眠阶段的出现频率，同时快速眼动睡眠阶段的发生率降低，并且减少了睡眠状态和慢波睡眠阶段的平均持续时间。海马切除术还显著增加了仅包含一个慢波睡眠阶段的睡眠序列的出现频率，代价是慢波睡眠和快速眼动睡眠交替出现的序列。海马切除术后，睡眠的昼夜变化不仅得以保留，实际上还被放大了。推测海马体有助于睡眠的快速眼动睡眠以及慢波睡眠阶段。
