Mine K, Miyairi N, Takano N, Mori S, Watanabe N
Antimicrob Agents Chemother. 1972 Jun;1(6):496-503. doi: 10.1128/AAC.1.6.496.
Thiopeptin is a new antibiotic, produced by Streptomyces tateyamensis and developed solely for animal use as a feed additive. The antibiotic content in animal tissue and feed was assayed in terms of the antimicrobial activity against Mycoplasma laidlawii A. This antibiotic was found to be relatively nontoxic in rats and mice. In chickens, this antibiotic is excreted into feces within 48 hr of administration and is not absorbed in tissue. It is well tolerated in both broilers and swine and is highly stable in animal feed. Thiopeptin-supplemented feed contributes to the improvement of weight gain, feed efficiency in chickens and swine, and the egg performance in layers. Thus, thiopeptin, when used as a feed additive, is quite suitable for supplementing animal nutrition.
硫肽菌素是一种新型抗生素，由立山链霉菌产生，专为动物作为饲料添加剂而开发。动物组织和饲料中的抗生素含量通过针对莱氏无胆甾原体A的抗菌活性进行测定。这种抗生素在大鼠和小鼠中相对无毒。在鸡中，这种抗生素在给药后48小时内排泄到粪便中，不会被组织吸收。它在肉鸡和猪中耐受性良好，在动物饲料中高度稳定。添加硫肽菌素的饲料有助于提高鸡和猪的体重增加、饲料效率以及蛋鸡的产蛋性能。因此，硫肽菌素用作饲料添加剂时，非常适合补充动物营养。
