Beck W
Hum Genet. 1979;50(1):93-100. doi: 10.1007/BF00295595.
A total of 13 metabolites thought to be possibly inhibitory were tested for their influence on PGM isozyme activities, each at several different concentrations. The analysis of statistical significance was based on enzyme activities obtained by densitometric measurements of starch gels. Five of the substances were found to inhibit PGM activity, three of which definitely and a further one probably led to a significantly stronger inhibition of the isozymes of the PGM2 locus than of PGM1 isozymes. They are (1) fructose-1,6-diphosphate, (2) adenosine triphosphate, (3) citrate, and (4) possibly 2,3-diphosphoglycerate. Thus, PGM1 isozymes proved to function better in hard or perhaps marginal metabolic conditions. Related evolutionary aspects are discussed.
总共测试了13种被认为可能具有抑制作用的代谢物对磷酸葡萄糖变位酶（PGM）同工酶活性的影响，每种代谢物都设置了几个不同的浓度。统计显著性分析基于通过淀粉凝胶密度测量获得的酶活性。发现其中5种物质可抑制PGM活性，其中3种肯定会，另一种可能会导致对PGM2位点同工酶的抑制作用明显强于对PGM1同工酶的抑制作用。它们是（1）果糖-1,6-二磷酸，（2）三磷酸腺苷，（3）柠檬酸，以及（4）可能的2,3-二磷酸甘油酸。因此，PGM1同工酶在艰难或可能处于边缘的代谢条件下功能更佳。文中还讨论了相关的进化方面。
