Ward P A, Talamo R C
J Clin Invest. 1973 Feb;52(2):516-9. doi: 10.1172/JCI107209.
As revealed by appropriate fractionation procedures, human serum deficient in alpha(1)-antitrypsin (alpha(1)-AT) is also deficient in the naturally occurring chemotactic factor inactivator. These serum donors had severe pulmonary emphysema. Serum from patients with clinically similar pulmonary disease, but with presence of alpha(1)-AT in the serum, showed no such deficiency of the chemotactic factor inactivator. When normal human serum and alpha(1)-AT-deficient human sera are chemotactically activated by incubation with immune precipitates, substantially more chemotactic activity is generated in alpha(1)-AT-deficient serum. These data indicate that in alpha(1)-AT-deficient serum there is an imbalance in the generation and control of chemotactic factors. It is suggested that the theory regarding development of pulmonary emphysema in patients lacking the alpha(1)-antitrypsin in their serum should be modified to take into account a deficiency of the chemotactic factor inactivator.
通过适当的分级分离程序发现，缺乏α1-抗胰蛋白酶（α1-AT）的人血清中天然存在的趋化因子灭活剂也缺乏。这些血清供体患有严重的肺气肿。患有临床症状相似的肺部疾病但血清中存在α1-AT的患者的血清，未显示出趋化因子灭活剂的这种缺乏。当正常人血清和缺乏α1-AT的人血清与免疫沉淀物一起孵育进行趋化激活时，缺乏α1-AT的血清中产生的趋化活性要高得多。这些数据表明，在缺乏α1-AT的血清中，趋化因子的产生和控制存在失衡。有人提出，关于血清中缺乏α1-抗胰蛋白酶的患者肺气肿发展的理论应加以修正，以考虑趋化因子灭活剂的缺乏。
